Phenotypes associated with this allele

• Allele Symbol: Oprl1^tm1Hta
• Allele Name: targeted mutation 1, Hiroshi Takeshima
• Allele ID: MGI:2181784
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprl1^tm1Hta/Oprl1^tm1Hta	involves: 129S4/SvJae	MGI:3621374
hm2	Oprl1^tm1Hta/Oprl1^tm1Hta	involves: 129S4/SvJae * C57BL/6J	MGI:3055961

Genotype
MGI:3621374

hm1

• Allelic Composition: Oprl1^tm1Hta/Oprl1^tm1Hta
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal mechanical nociception ( J:107151 )

• response to mechanical allodynia induced by intrathecal administration of nociceptin FQ weaker in mutants which exhibit slight responses in the first 20 minutes while wild-type mice exhibit strong allodynic responses over the 50-minute experimental period

• injection of PGE2 intrathecally induces allodynia in wild-type mice but not in mutants

Genotype
MGI:3055961

hm2

• Allelic Composition: Oprl1^tm1Hta/Oprl1^tm1Hta
• Genetic Background: involves: 129S4/SvJae * C57BL/6J

behavior/neurological

impaired behavioral response to morphine ( J:70568 )

• resistant to morphine analgesic tolerance in tail-pinch and tail-flick tests after repeated administration

• attenuation of morphine-induced physical dependence

abnormal learning/memory/conditioning ( J:49161 )

abnormal passive avoidance behavior ( J:49161 )

• increased retention of passive avoidance memory

abnormal response to new environment ( J:49161 )

• improved performance in water-finding task

abnormal spatial learning ( J:49161 )

• improved performance in Morris water maze

abnormal touch/ nociception ( J:39955 )

abnormal chemical nociception ( J:39955 , J:89677 )

• loss of nociceptin-induced hypolocomotion (J:39955)

• increase in nociceptive responses in phase II of formalin test (J:89677)

decreased chemically-elicited antinociception ( J:70569 )

• administration of opioid receptor antagonist does not diminish acetic acid-induced writhing response

decreased thermal nociceptive threshold ( J:89677 )

• decreased paw withdrawal latency of inflamed paw in inflammatory thermal hyperalgesia test

hearing/vestibular/ear

increased susceptibility to noise-induced hearing loss ( J:39955 )

• auditory brainstem response threshold temporarily increased following intense sound as compared to wildtype

nervous system

enhanced long-term potentiation ( J:49161 )

• larger long-term potentiation in the hippocampal CA1

homeostasis/metabolism

increased dopamine level ( J:90602 )

• increased mesolimbic dopamine release upon administration of opioid peptide agonist