mortality/aging
• die between E10 and E12.5
(J:50761)
|
cardiovascular system
• at E10 the vasculature is underdeveloped; however differentiation of endothelial cells is normal
|
• at E9.0 irregularly formed large vessels (anterior cardinal veins and dorsal aorta) with defective lumens are seen
|
• at E9.0 irregularly formed large vessels (anterior cardinal veins and dorsal aorta) with defective lumens are seen
|
• at E9.5 an immature perineural vascular plexus is still present, unlike in wild-type and heterozygous mice where vascular remodeling has occurred
• however, sprouting angiogenesis apparently occurs, as shown by the presence of intersomitic vessels
|
• occasional
|
embryo
• at E10
|
pale yolk sac
(
J:50761
)
• at E10
|
• at E10, major blood vessels are absent probably a result of failure to remodel the primitive vascular plexus
|
homeostasis/metabolism
• occasional
|
growth/size/body
• at E10
|