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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Flt4tm1Ali
targeted mutation 1, Kari Alitalo
MGI:2181789
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Flt4tm1Ali/Flt4tm1Ali Not Specified MGI:3620110
ht2
Flt4tm1Ali/Flt4tm2Ali involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3805318
ht3
Flt4Chy/Flt4tm1Ali involves: C3H MGI:3620109
cn4
Flt4tm1Ali/Flt4tm2.1Ali
Krt19tm1(cre)Mmt/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL MGI:3805321
cx5
Flt4tm1Ali/Flt4+
Tmem204tm1.1Ali/Tmem204tm1.1Ali
involves: BALB/c * C57BL/6 MGI:4454672
cx6
Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2tm1Ddg
involves: C57BL/6 MGI:4429925
cx7
Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2+
involves: C57BL/6 MGI:4429922
cx8
Efnb2tm5.1Kln/Efnb2tm5.1Kln
Flt4tm1Ali/Flt4+
involves: C57BL/6 MGI:3574341


Genotype
MGI:3620110
hm1
Allelic
Composition
Flt4tm1Ali/Flt4tm1Ali
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• at E10 the vasculature is underdeveloped; however differentiation of endothelial cells is normal
• at E9.0 irregularly formed large vessels (anterior cardinal veins and dorsal aorta) with defective lumens are seen
• at E9.0 irregularly formed large vessels (anterior cardinal veins and dorsal aorta) with defective lumens are seen
• at E9.5 an immature perineural vascular plexus is still present, unlike in wild-type and heterozygous mice where vascular remodeling has occurred
• however, sprouting angiogenesis apparently occurs, as shown by the presence of intersomitic vessels
• occasional

embryo
• at E10
• at E10, major blood vessels are absent probably a result of failure to remodel the primitive vascular plexus

homeostasis/metabolism
• occasional

growth/size/body




Genotype
MGI:3805318
ht2
Allelic
Composition
Flt4tm1Ali/Flt4tm2Ali
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (77 available)
Flt4tm2Ali mutation (0 available); any Flt4 mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• absence of lymphatic vessels in the skin and mesenterium at E18.5




Genotype
MGI:3620109
ht3
Allelic
Composition
Flt4Chy/Flt4tm1Ali
Genetic
Background
involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4Chy mutation (2 available); any Flt4 mutation (77 available)
Flt4tm1Ali mutation (1 available); any Flt4 mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no pups are born alive

growth/size/body

embryo




Genotype
MGI:3805321
cn4
Allelic
Composition
Flt4tm1Ali/Flt4tm2.1Ali
Krt19tm1(cre)Mmt/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (77 available)
Flt4tm2.1Ali mutation (2 available); any Flt4 mutation (77 available)
Krt19tm1(cre)Mmt mutation (0 available); any Krt19 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• phenotype is stated to be identical to that of Flttm1Ali homozygotes

cardiovascular system
• blood vessel defects identical to those in Flttm1Ali homozygotes




Genotype
MGI:4454672
cx5
Allelic
Composition
Flt4tm1Ali/Flt4+
Tmem204tm1.1Ali/Tmem204tm1.1Ali
Genetic
Background
involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (77 available)
Tmem204tm1.1Ali mutation (0 available); any Tmem204 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• abnormal smooth muscle cell coating
• enlarged lymphatic vessels are even more dilated than in Tmem204tm1.1Ali single knock-outs

muscle
• abnormal smooth muscle cell coating




Genotype
MGI:4429925
cx6
Allelic
Composition
Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (77 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• enlarged lymph vessel in the dorsal trunk skin at P0
• poor branching in the dorsal trunk skin at P0 (<5%, compare with wild-type)




Genotype
MGI:4429922
cx7
Allelic
Composition
Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (77 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (89 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Abnormal lymphatic development in Nrp2tm1Ddg/Nrp2+ Flt4tm1Ali/Flt4+ mice

mortality/aging
• recovered at reduced Mendelian ratios at birth

homeostasis/metabolism
• edema formation observed by histology at E13.5
• severe edema formation from E15.5 onward

immune system
• poorly branched lymphatic vessels and rare lymphatic tips in the skin at P0
• 50% reduction in the number of branch points in the skin at P0
• reduced lymph vessel branching in hearts, ears and diaphragm at 2 months
• tail dermal lymphatics are missing until at least P6
• reduced lymphatic vascular coverage in the skin at E13.5
• reduced sprouting and enlarged lymphatic vessels in the skin at E13.5, in the tail at P1, in the heart at P5 and in the small intestine at P4

integument
• edema formation observed by histology at E13.5
• severe edema formation from E15.5 onward




Genotype
MGI:3574341
cx8
Allelic
Composition
Efnb2tm5.1Kln/Efnb2tm5.1Kln
Flt4tm1Ali/Flt4+
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm5.1Kln mutation (0 available); any Efnb2 mutation (29 available)
Flt4tm1Ali mutation (1 available); any Flt4 mutation (77 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• reduction or absence of the formation of the superficial capillary plexus/network due to the disruption of endothelial cell sprouting, with the cells failing to take the characteristic elongated morphology and instead having the mutant lymphatic vascular plexus depicting few rounded bumps
• failed to remodel the primary lymphatic capillary plexus into a hierarchical vessel network
• hyperplastic collecting lymphatic vessels in the ischiatic vein region and in the skin





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory