Phenotypes associated with this allele

• Allele Symbol: Ryr3^tm1Vso
• Allele Name: targeted mutation 1, Vincenzo Sorrentino
• Allele ID: MGI:2181794
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ryr3^tm1Vso/Ryr3^tm1Vso	involves: 129P2/OlaHsd	MGI:3623004
hm2	Ryr3^tm1Vso/Ryr3^tm1Vso	involves: 129P2/OlaHsd * C57BL/6	MGI:3623003

Genotype
MGI:3623004

hm1

• Allelic Composition: Ryr3^tm1Vso/Ryr3^tm1Vso
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle contractility ( J:106292 )

• spontaneous discrete events of calcium release in mutant myotubes are of longer duration than those in wild-type

Genotype
MGI:3623003

hm2

• Allelic Composition: Ryr3^tm1Vso/Ryr3^tm1Vso
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

muscle

abnormal muscle contractility ( J:45244 )

• time to peak tension becomes shorter in adult mutant muscle preparations compared to neonatal preparations

impaired muscle contractility ( J:45244 )

• in neonatal (15 day old) mutant mice, the tension developed in a twitch at low frequency or that develop in an unfused tetani is lower than that in wild-type preparations; the force-frequency curve is shifted down and rightward in nulls

• contracture of diaphragm muscle induced by caffeine is strongly reduced in mutant muscle compared to wild-type neonatal muscle; response to caffeine is almost abolished in mutant neonatal diaphragm muscle and significantly reduced in the extensor digitorum longus and soleus muscles