muscle
• spontaneous discrete events of calcium release in mutant myotubes are of longer duration than those in wild-type
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Allele Symbol Allele Name Allele ID |
Ryr3tm1Vso targeted mutation 1, Vincenzo Sorrentino MGI:2181794 |
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Summary |
2 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• spontaneous discrete events of calcium release in mutant myotubes are of longer duration than those in wild-type
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• time to peak tension becomes shorter in adult mutant muscle preparations compared to neonatal preparations
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• in neonatal (15 day old) mutant mice, the tension developed in a twitch at low frequency or that develop in an unfused tetani is lower than that in wild-type preparations; the force-frequency curve is shifted down and rightward in nulls
• contracture of diaphragm muscle induced by caffeine is strongly reduced in mutant muscle compared to wild-type neonatal muscle; response to caffeine is almost abolished in mutant neonatal diaphragm muscle and significantly reduced in the extensor digitorum longus and soleus muscles
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/21/2024 MGI 6.24 |
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