All Phenotypes Mest<tm1Masu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mest^tm1Masu/Mest⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2677273
ht2	Mest^tm1Masu/Mest⁺	involves: BALB/c	MGI:2677275
ht3	Mest^tm1Masu/Mest⁺	involves: C57BL/6	MGI:2677274
ht4	Mest^tm1Masu/Mest⁺	involves: C57BL/6 * CBA/Ca	MGI:2677276

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:50170 )

• increased perinatal lethality when mutant allele inherited paternally

postnatal lethality, incomplete penetrance ( J:50170 )

• reduced growth during the first week of life, after which mutant mice grew in parallel to wild-type mice when mutant allele inherited paternally

cardiovascular system

abnormal myocardium layer morphology ( J:79223 )

• increased thickness and reduced density of compact myocardium when mutat allele inherited paternally, similar to that seen in human cardiomyopathy ventricular noncompaction

abnormal myocardial trabeculae morphology ( J:79223 )

• subtle alteration in the pattern of trabeculation when mutant allele inherited paternally

behavior/neurological

abnormal maternal nurturing ( J:50170 )

• parturient females exhibited reduced placentophagic behavior (ingestion of extraembryonic tissues) when mutant allele inherited paternally

abnormal pup retrieval ( J:50170 )

• the failure to retrieve pups was not associated with impaired olfactory function when mutant allele inherited paternally

muscle

abnormal myocardium layer morphology ( J:79223 )

• increased thickness and reduced density of compact myocardium when mutat allele inherited paternally, similar to that seen in human cardiomyopathy ventricular noncompaction

abnormal myocardial trabeculae morphology ( J:79223 )

• subtle alteration in the pattern of trabeculation when mutant allele inherited paternally

embryo

small placenta ( J:50170 )

• although reduced in size the structures of the spongiotrophoblast and labyrinthine trophoblast were normal when mutant allele inherited paternally

decreased placenta weight ( J:50170 )

• placental weights were 86.4% those of wild-type when mutant allele inherited paternally

growth/size/body

decreased body weight ( J:50170 )

• average weight was 65% that of wild-type at 7 days of age when mutant allele inherited paternally

decreased fetal size ( J:50170 )

• fetuses were signficantly smaller than wild-type at E18.5 when mutant allele inherited paternally

• fetal weights were 87.5% those of wild-type when mutant allele inherited paternally

decreased fetal weight ( J:50170 )

• fetal weights were 87.5% those of wild-type when mutant allele inherited paternally

skeleton

skeleton phenotype ( J:50170 )

N	• no skeletal abnormalities detected identified by x-ray radiograms when mutant allele inherited paternally

cellular

maternal imprinting ( J:50170 , J:79223 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Barth syndrome		DOID:0050476	OMIM:302060	J:79223

Allelic Composition	Mest^tm1Masu/Mest⁺
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mest^tm1Masu mutation (0 available); any Mest mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allele inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

growth/size/body

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allele inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

cellular

maternal imprinting ( J:50170 )

Allelic Composition	Mest^tm1Masu/Mest⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mest^tm1Masu mutation (0 available); any Mest mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allelle inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

growth/size/body

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allelle inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

cellular

maternal imprinting ( J:50170 )

Allelic Composition	Mest^tm1Masu/Mest⁺
Genetic Background	involves: C57BL/6 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mest^tm1Masu mutation (0 available); any Mest mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allele inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

growth/size/body

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allele inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

cellular

maternal imprinting ( J:50170 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24