All Phenotypes Mest<tm1Masu> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mest^tm1Masu/Mest⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2677273
ht2	Mest^tm1Masu/Mest⁺	involves: BALB/c	MGI:2677275
ht3	Mest^tm1Masu/Mest⁺	involves: C57BL/6	MGI:2677274
ht4	Mest^tm1Masu/Mest⁺	involves: C57BL/6 * CBA/Ca	MGI:2677276

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:50170 )

• increased perinatal lethality when mutant allele inherited paternally

postnatal lethality, incomplete penetrance ( J:50170 )

• reduced growth during the first week of life, after which mutant mice grew in parallel to wild-type mice when mutant allele inherited paternally

cardiovascular system

abnormal myocardium layer morphology ( J:79223 )

• increased thickness and reduced density of compact myocardium when mutat allele inherited paternally, similar to that seen in human cardiomyopathy ventricular noncompaction

abnormal myocardial trabeculae morphology ( J:79223 )

• subtle alteration in the pattern of trabeculation when mutant allele inherited paternally

behavior/neurological

abnormal maternal nurturing ( J:50170 )

• parturient females exhibited reduced placentophagic behavior (ingestion of extraembryonic tissues) when mutant allele inherited paternally

abnormal pup retrieval ( J:50170 )

• the failure to retrieve pups was not associated with impaired olfactory function when mutant allele inherited paternally

muscle

abnormal myocardium layer morphology ( J:79223 )

• increased thickness and reduced density of compact myocardium when mutat allele inherited paternally, similar to that seen in human cardiomyopathy ventricular noncompaction

abnormal myocardial trabeculae morphology ( J:79223 )

• subtle alteration in the pattern of trabeculation when mutant allele inherited paternally

embryo

small placenta ( J:50170 )

• although reduced in size the structures of the spongiotrophoblast and labyrinthine trophoblast were normal when mutant allele inherited paternally

decreased placenta weight ( J:50170 )

• placental weights were 86.4% those of wild-type when mutant allele inherited paternally

growth/size/body

decreased body weight ( J:50170 )

• average weight was 65% that of wild-type at 7 days of age when mutant allele inherited paternally

decreased fetal size ( J:50170 )

• fetal weights were 87.5% those of wild-type when mutant allele inherited paternally

• fetuses were signficantly smaller than wild-type at E18.5 when mutant allele inherited paternally

decreased fetal weight ( J:50170 )

• fetal weights were 87.5% those of wild-type when mutant allele inherited paternally

skeleton

skeleton phenotype ( J:50170 )

N	• no skeletal abnormalities detected identified by x-ray radiograms when mutant allele inherited paternally

cellular

maternal imprinting ( J:50170 , J:79223 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Barth syndrome		DOID:0050476	OMIM:302060	J:79223

Allelic Composition	Mest^tm1Masu/Mest⁺
Genetic Background	involves: BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mest^tm1Masu mutation (0 available); any Mest mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allele inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

growth/size/body

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allele inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

cellular

maternal imprinting ( J:50170 )

Allelic Composition	Mest^tm1Masu/Mest⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mest^tm1Masu mutation (0 available); any Mest mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allelle inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

growth/size/body

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allelle inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

cellular

maternal imprinting ( J:50170 )

Allelic Composition	Mest^tm1Masu/Mest⁺
Genetic Background	involves: C57BL/6 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mest^tm1Masu mutation (0 available); any Mest mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allele inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

growth/size/body

decreased embryo size ( J:50170 )

• embryonic growth defect when mutant allele inherited paternally reported to be less severe than that observed on an 129/Sv inbred background

cellular

maternal imprinting ( J:50170 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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