All Phenotypes Gja4<tm1Paul> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gja4^tm1Paul/Gja4^tm1Paul	either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)	MGI:2651405
cx2	Gja4^tm1Paul/Gja4^tm1Paul Gja5^tm1Paul/Gja5^tm1Paul	involves: 129S4/SvJae * C57BL/6	MGI:3629933

Allelic Composition	Gja4^tm1Paul/Gja4^tm1Paul
Genetic Background	either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gja4^tm1Paul mutation (1 available); any Gja4 mutation (15 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal female meiosis ( J:38247 )

abnormal corpus luteum morphology ( J:38247 )

• premature formation of corpora lutea

anovulation ( J:38247 )

• absence of ovulation

female infertility ( J:38247 )

endocrine/exocrine glands

abnormal corpus luteum morphology ( J:38247 )

• premature formation of corpora lutea

cellular

abnormal female meiosis ( J:38247 )

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:80178 )

• animals died within 2 days after birth

lethality throughout fetal growth and development, incomplete penetrance ( J:80178 )

• incomplete penetrance; reduced embryonic viability at E14.5

neonatal lethality, incomplete penetrance ( J:80178 )

• animals died within 2 days after birth

reproductive system

abnormal testis morphology ( J:80178 )

• extensive blood filled region of testes; congested, thin walled vascular channels in between testicular cord tissue

abnormal spermatogenesis ( J:80178 )

• mild to severe sperm vacuolar degeneration and necrosis

cardiovascular system

blood vessel congestion ( J:80178 )

lung hemorrhage ( J:80178 )

• 45% of animals displayed blood-filled lungs

gastrointestinal hemorrhage ( J:80178 )

• enlarged blood vessels in intestinal or gastric wall

increased vasodilation ( J:80178 )

• dilated blood vessels observed in skin near hematomas; subcutaneous hematomas observed on dorsal surface of the animal, especially on the head and also on the neck, shoulders, and posterior regions

digestive/alimentary system