All Phenotypes Dazl<tm1Hjc> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dazl^tm1Hjc
targeted mutation 1, Howard J Cooke
MGI:2181904

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dazl^tm1Hjc/Dazl^tm1Hjc	involves: 129P2/OlaHsd * MF1	MGI:2659051
ht2	Dazl^tm1Hjc/Dazl⁺	involves: 129P2/OlaHsd * MF1	MGI:2659052
cx3	Dazl^tm1Hjc/Dazl⁺ Pum2^Gt(XE772)Byg/Pum2^Gt(XE772)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:3813702

Allelic Composition	Dazl^tm1Hjc/Dazl^tm1Hjc
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dazl^tm1Hjc mutation (3 available); any Dazl mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

absent ovarian follicles ( J:42612 )

• neither follicles nor ova were observed

small ovary ( J:42612 )

abnormal seminiferous tubule morphology ( J:42612 , J:71070 )

• fewer tubules per cross-section (J:42612)

• reduced tubule diameter relative to wild-type (J:71070)

small testis ( J:42612 )

• 3-fold reduction in testis mass relative to wild-type littermates

reproductive system

absent ovarian follicles ( J:42612 )

• neither follicles nor ova were observed

small ovary ( J:42612 )

abnormal seminiferous tubule morphology ( J:42612 , J:71070 )

• fewer tubules per cross-section (J:42612)

• reduced tubule diameter relative to wild-type (J:71070)

small testis ( J:42612 )

• 3-fold reduction in testis mass relative to wild-type littermates

arrest of spermatogenesis ( J:42612 , J:71070 )

(J:42612)

• spermatogonia were contained within 76% of adult tubules (J:71070)

• spermatocytes were contained within 3% of adult tubules (J:71070)

• failure of A aligned spermatogonia to differentiate into A1 spermatogonia (J:71070)

female infertility ( J:42612 )

male infertility ( J:42612 )

Allelic Composition	Dazl^tm1Hjc/Dazl⁺
Genetic Background	involves: 129P2/OlaHsd * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dazl^tm1Hjc mutation (3 available); any Dazl mutation (32 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male germ cell morphology ( J:42612 )

• 60% of sperm are visibly abnormal

oligozoospermia ( J:42612 )

• reduced amount of epididymal sperm

cellular

abnormal male germ cell morphology ( J:42612 )

• 60% of sperm are visibly abnormal

oligozoospermia ( J:42612 )

• reduced amount of epididymal sperm

Allelic Composition	Dazl^tm1Hjc/Dazl⁺ Pum2^Gt(XE772)Byg/Pum2^Gt(XE772)Byg
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dazl^tm1Hjc mutation (3 available); any Dazl mutation (32 available)
Pum2^Gt(XE772)Byg mutation (1 available); any Pum2 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:123531 )

N	• males are fertile with sperm counts that do not differ significantly from controls unlike mice homozygous for Dazl^tm1Hjc

decreased testis weight ( J:123531 )

endocrine/exocrine glands

decreased testis weight ( J:123531 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24