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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Del(3Cd1d2-Cd1d1)1Crw
deletion, Chr 3, Chyung-Ru Wang 1
MGI:2181950
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw involves: 129S4/SvJae * C57BL/6 MGI:2661989
cx2
Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw
TcraLn1Ogu/Tcra+
involves: 129/Sv * C57BL/6 MGI:4356165
cx3
Cd1d1tm2Aben/Del(3Cd1d2-Cd1d1)1Crw involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:5056353
cx4
Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw
Tg(TcraAV19AJ33)1Shima/0
involves: 129S4/SvJae * C57BL/6 MGI:3831164


Genotype
MGI:2661989
hm1
Allelic
Composition
Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mice exhibit a reduction in the numbers of CD4+ Valpha3.2-Vbeta8 T cells compared with wild-type mice
• 60-80% reduction in NK1+ T cells, particularly those with a canonical gene rearrangement of Valpha14-Jalpha281 (J:39749)
• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested (J:76976)
• there is about a 80% reduction in the number of NK T cells found in the liver from 11.5% of total liver lymphocytes to 2.3% in the mutant liver (J:112657)
• mice exhibit a reduction of Valpha14 NKT cells in the spleen and liver compared with wild-type mice (J:174337)
• activated NK T cells isolated from livers of these mice secrete less IFN-gamma, TNF, and IL-4 than wild-type NK T cells
• thymocytes exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells
• mutants show impaired IL-4 production after stimulation with anti-CD3 antibodies, however they are able to generate antigen-specific Th2 responses

hematopoietic system
• mice exhibit a reduction in the numbers of CD4+ Valpha3.2-Vbeta8 T cells compared with wild-type mice
• 60-80% reduction in NK1+ T cells, particularly those with a canonical gene rearrangement of Valpha14-Jalpha281 (J:39749)
• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested (J:76976)
• there is about a 80% reduction in the number of NK T cells found in the liver from 11.5% of total liver lymphocytes to 2.3% in the mutant liver (J:112657)
• mice exhibit a reduction of Valpha14 NKT cells in the spleen and liver compared with wild-type mice (J:174337)
• activated NK T cells isolated from livers of these mice secrete less IFN-gamma, TNF, and IL-4 than wild-type NK T cells




Genotype
MGI:4356165
cx2
Allelic
Composition
Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw
TcraLn1Ogu/Tcra+
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(3Cd1d2-Cd1d1)1Crw mutation (0 available); any Del(3Cd1d2-Cd1d1)1Crw mutation (0 available)
TcraLn1Ogu mutation (0 available); any Tcra mutation (101 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• less invariant NKT cells mature in the thymus as determined by binding to CD1d tetramers
• immature iNKT cells that are CD24+CD44dullNK1.1- are very abundant in the thymus

hematopoietic system
• less invariant NKT cells mature in the thymus as determined by binding to CD1d tetramers
• immature iNKT cells that are CD24+CD44dullNK1.1- are very abundant in the thymus




Genotype
MGI:5056353
cx3
Allelic
Composition
Cd1d1tm2Aben/Del(3Cd1d2-Cd1d1)1Crw
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm2Aben mutation (1 available); any Cd1d1 mutation (35 available)
Del(3Cd1d2-Cd1d1)1Crw mutation (0 available); any Del(3Cd1d2-Cd1d1)1Crw mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• peritoneal macrophages exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells




Genotype
MGI:3831164
cx4
Allelic
Composition
Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw
Tg(TcraAV19AJ33)1Shima/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• the number of total NK T cell numbers are normal but the majority of NK T cells is shifted from expressing a Valpha14 to Valpha19 TCR-alpha chain
• these transgenic TCR-alpha chain associate with TCR-beta V6 or V8 chains 60-70% of the time compared to 'conventional T cells' that associate with the above beta chains about 40% of the time
• nave transgenic NK T cells display a memory phenotype with more surface expression of the costimulatory molecules CD278, CD86, CD154, CD44 and CD28 than do naive splenic T cells

immune system
• the number of total NK T cell numbers are normal but the majority of NK T cells is shifted from expressing a Valpha14 to Valpha19 TCR-alpha chain
• these transgenic TCR-alpha chain associate with TCR-beta V6 or V8 chains 60-70% of the time compared to 'conventional T cells' that associate with the above beta chains about 40% of the time
• nave transgenic NK T cells display a memory phenotype with more surface expression of the costimulatory molecules CD278, CD86, CD154, CD44 and CD28 than do naive splenic T cells
• transgenic NK T cells isolated from these mice induce IL-10 secretion from CD19+ B cells and other NK T cells
• the progression and development of MOG-induced EAE is suppressed in these mice compared to both wild-type and Cd1d1/Cd1d2tm1Crw homozygotes
• mean severity score is 1.3 versus 3.3 in wild-type controls
• mice at day 15 post induction have 3-fold less infiltrating mononuclear cells in their spinal cord with a lower percentage of CD4+ T cells making up the infiltrate (6% of infiltrating cells vs 21% in littermate controls)
• memory T cells isolated from mice 10 days after disease induction produce less inflammatory cytokines (IFN-g, TNF, IL-2 and IL-17) and more IL-10
• mean day of onset is 14.3 compared to 13.6 for wild-type controls





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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory