All Phenotypes Del(3Cd1d2-Cd1d1)1Crw MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw	involves: 129S4/SvJae * C57BL/6	MGI:2661989
cx2	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tcra^Ln1Ogu/Tcra⁺	involves: 129/Sv * C57BL/6	MGI:4356165
cx3	Cd1d1^tm2Aben/Del(3Cd1d2-Cd1d1)1Crw	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5056353
cx4	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tg(TcraAV19AJ33)1Shima/0	involves: 129S4/SvJae * C57BL/6	MGI:3831164

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:174337 )

• mice exhibit a reduction in the numbers of CD4+ Valpha3.2-Vbeta8 T cells compared with wild-type mice

decreased NK T cell number ( J:39749 , J:76976 , J:112657 , J:174337 )

• 60-80% reduction in NK1+ T cells, particularly those with a canonical gene rearrangement of Valpha14-Jalpha281 (J:39749)

• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested (J:76976)

• there is about a 80% reduction in the number of NK T cells found in the liver from 11.5% of total liver lymphocytes to 2.3% in the mutant liver (J:112657)

• mice exhibit a reduction of Valpha14 NKT cells in the spleen and liver compared with wild-type mice (J:174337)

abnormal NK T cell physiology ( J:112657 )

• activated NK T cells isolated from livers of these mice secrete less IFN-gamma, TNF, and IL-4 than wild-type NK T cells

abnormal antigen presentation ( J:174337 )

• thymocytes exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells

decreased interleukin-4 secretion ( J:39749 )

• mutants show impaired IL-4 production after stimulation with anti-CD3 antibodies, however they are able to generate antigen-specific Th2 responses

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:174337 )

• mice exhibit a reduction in the numbers of CD4+ Valpha3.2-Vbeta8 T cells compared with wild-type mice

decreased NK T cell number ( J:39749 , J:76976 , J:112657 , J:174337 )

• 60-80% reduction in NK1+ T cells, particularly those with a canonical gene rearrangement of Valpha14-Jalpha281 (J:39749)

• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested (J:76976)

• there is about a 80% reduction in the number of NK T cells found in the liver from 11.5% of total liver lymphocytes to 2.3% in the mutant liver (J:112657)

• mice exhibit a reduction of Valpha14 NKT cells in the spleen and liver compared with wild-type mice (J:174337)

abnormal NK T cell physiology ( J:112657 )

• activated NK T cells isolated from livers of these mice secrete less IFN-gamma, TNF, and IL-4 than wild-type NK T cells

Allelic Composition	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tcra^Ln1Ogu/Tcra⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(3Cd1d2-Cd1d1)1Crw mutation (0 available); any Del(3Cd1d2-Cd1d1)1Crw mutation (0 available)
Tcra^Ln1Ogu mutation (0 available); any Tcra mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal NK T cell morphology ( J:152041 )

• less invariant NKT cells mature in the thymus as determined by binding to CD1d tetramers

• immature iNKT cells that are CD24⁺CD44^dullNK1.1^- are very abundant in the thymus

hematopoietic system

abnormal NK T cell morphology ( J:152041 )

• less invariant NKT cells mature in the thymus as determined by binding to CD1d tetramers

• immature iNKT cells that are CD24⁺CD44^dullNK1.1^- are very abundant in the thymus

Allelic Composition	Cd1d1^tm2Aben/Del(3Cd1d2-Cd1d1)1Crw
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1^tm2Aben mutation (1 available); any Cd1d1 mutation (35 available)
Del(3Cd1d2-Cd1d1)1Crw mutation (0 available); any Del(3Cd1d2-Cd1d1)1Crw mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal antigen presentation ( J:174337 )

• peritoneal macrophages exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells

Allelic Composition	Del(3Cd1d2-Cd1d1)1Crw/Del(3Cd1d2-Cd1d1)1Crw Tg(TcraAV19AJ33)1Shima/0
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal NK T cell morphology ( J:112657 )

• the number of total NK T cell numbers are normal but the majority of NK T cells is shifted from expressing a Valpha14 to Valpha19 TCR-alpha chain

• these transgenic TCR-alpha chain associate with TCR-beta V6 or V8 chains 60-70% of the time compared to 'conventional T cells' that associate with the above beta chains about 40% of the time

• nave transgenic NK T cells display a memory phenotype with more surface expression of the costimulatory molecules CD278, CD86, CD154, CD44 and CD28 than do naive splenic T cells

immune system

abnormal NK T cell morphology ( J:112657 )

• the number of total NK T cell numbers are normal but the majority of NK T cells is shifted from expressing a Valpha14 to Valpha19 TCR-alpha chain

• these transgenic TCR-alpha chain associate with TCR-beta V6 or V8 chains 60-70% of the time compared to 'conventional T cells' that associate with the above beta chains about 40% of the time

• nave transgenic NK T cells display a memory phenotype with more surface expression of the costimulatory molecules CD278, CD86, CD154, CD44 and CD28 than do naive splenic T cells

increased interleukin-10 secretion ( J:112657 )

• transgenic NK T cells isolated from these mice induce IL-10 secretion from CD19⁺ B cells and other NK T cells

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:112657 )

• the progression and development of MOG-induced EAE is suppressed in these mice compared to both wild-type and Cd1d1/Cd1d2^tm1Crw homozygotes

• mean severity score is 1.3 versus 3.3 in wild-type controls

• mice at day 15 post induction have 3-fold less infiltrating mononuclear cells in their spinal cord with a lower percentage of CD4⁺ T cells making up the infiltrate (6% of infiltrating cells vs 21% in littermate controls)

• memory T cells isolated from mice 10 days after disease induction produce less inflammatory cytokines (IFN-g, TNF, IL-2 and IL-17) and more IL-10

• mean day of onset is 14.3 compared to 13.6 for wild-type controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24