immune system
• mice exhibit a reduction in the numbers of CD4+ Valpha3.2-Vbeta8 T cells compared with wild-type mice
|
• 60-80% reduction in NK1+ T cells, particularly those with a canonical gene rearrangement of Valpha14-Jalpha281
(J:39749)
• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested
(J:76976)
• there is about a 80% reduction in the number of NK T cells found in the liver from 11.5% of total liver lymphocytes to 2.3% in the mutant liver
(J:112657)
• mice exhibit a reduction of Valpha14 NKT cells in the spleen and liver compared with wild-type mice
(J:174337)
|
• activated NK T cells isolated from livers of these mice secrete less IFN-gamma, TNF, and IL-4 than wild-type NK T cells
|
• thymocytes exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells
|
• mutants show impaired IL-4 production after stimulation with anti-CD3 antibodies, however they are able to generate antigen-specific Th2 responses
|
hematopoietic system
• mice exhibit a reduction in the numbers of CD4+ Valpha3.2-Vbeta8 T cells compared with wild-type mice
|
• 60-80% reduction in NK1+ T cells, particularly those with a canonical gene rearrangement of Valpha14-Jalpha281
(J:39749)
• the percentage of NK T cells in the liver is reduced by 70% to 75% and by 60% to 75% in all other organs tested
(J:76976)
• there is about a 80% reduction in the number of NK T cells found in the liver from 11.5% of total liver lymphocytes to 2.3% in the mutant liver
(J:112657)
• mice exhibit a reduction of Valpha14 NKT cells in the spleen and liver compared with wild-type mice
(J:174337)
|
• activated NK T cells isolated from livers of these mice secrete less IFN-gamma, TNF, and IL-4 than wild-type NK T cells
|