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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lta4htm1Bhk
targeted mutation 1, Beverly H Koller
MGI:2182082
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lta4htm1Bhk/Lta4htm1Bhk involves: 129P2/OlaHsd * 129S/SvEv MGI:3581547


Genotype
MGI:3581547
hm1
Allelic
Composition		 Lta4htm1Bhk/Lta4htm1Bhk
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta4htm1Bhk mutation (1 available); any Lta4h mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased acute inflammation ( J:58985 )
• skin reactions reduced
• less protein leakage from the vasculature in skin reactions but not peritonitis
• reduced influx of polymorphonuclear leukocytes into peritoneal cavity
decreased susceptibility to type I hypersensitivity reaction ( J:58985 )
• reduced anaphylaxis induced by platelet activating factor but not by other methods




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory