Phenotypes associated with this allele

• Allele Symbol: Sox4^tm1Cle
• Allele Name: targeted mutation 1, Hans Clevers
• Allele ID: MGI:2182092
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sox4^tm1Cle/Sox4^tm1Cle	involves: 129P2/OlaHsd * C57BL/6	MGI:3029238

Genotype
MGI:3029238

hm1

• Allelic Composition: Sox4^tm1Cle/Sox4^tm1Cle
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:32741 )

• homozygous embryos died at E14

cardiovascular system

persistent right dorsal aorta ( J:51464 )

• both dorsal aortae were still present in 7 of 8 E13 mutant embryos, whereas the right dorsal aorta had disappeared in all control littermates

• by E14 the right dorsal aorta, if present, had diminished greatly in diameter in mutant embryos

abnormal coronary artery morphology ( J:51464 )

• at E13, only 25% of mutant ED13 hearts develop coronary arteries

abnormal conotruncal ridge morphology ( J:51464 )

• at E13 and E14, the two endocardial ridges were always present, but the number and position of intercalated ridges between them differed from controls

failure of conotruncal ridge closure ( J:32741 )

• abnormal endocardial ridges; never fused and failed to develop into semiluminar valves

abnormal aorticopulmonary septum morphology ( J:32741 )

• impaired development of the aortopulmonary septum

perimembraneous ventricular septal defect ( J:32741 )

• septation defect affected the outlet portion of the ventricles and the great arteries

abnormal semilunar valve morphology ( J:32741 )

• dysplasia of the valves

abnormal blood circulation ( J:32741 )

• oscillating blood flow

increased heart rate ( J:32741 )

hematopoietic system

abnormal B cell differentiation ( J:32741 )

• very few mature B cells are produced in irradiated mice reconstituted with mutant fetal liver cells

decreased pro-B cell number ( J:32741 )

• CD43+B220+ pro-B cell numbers were reduced

absent pre-B cells ( J:32741 )

• Cd43-B220+ pre-B cells were nearly absent

homeostasis/metabolism

hydrops fetalis ( J:32741 )

• generalized edema apparent at E14

immune system

abnormal B cell differentiation ( J:32741 )

• very few mature B cells are produced in irradiated mice reconstituted with mutant fetal liver cells

decreased pro-B cell number ( J:32741 )

• CD43+B220+ pro-B cell numbers were reduced

absent pre-B cells ( J:32741 )

• Cd43-B220+ pre-B cells were nearly absent

digestive/alimentary system

tracheoesophageal fistula ( J:51464 )

• observed in 4 mutant embryos

respiratory system

tracheoesophageal fistula ( J:51464 )

• observed in 4 mutant embryos