mortality/aging
• homozygous embryos died at E14
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cardiovascular system
• abnormal endocardial ridges; never fused and failed to develop into semiluminar valves
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• septation defect affected the outlet portion of the ventricles and the great arteries
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• dysplasia of the valves
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• oscillating blood flow
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hematopoietic system
• very few mature B cells are produced in irradiated mice reconstituted with mutant fetal liver cells
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• pro-B cell numbers were reduced
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• pre-B cells were nearly absent
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homeostasis/metabolism
• generalized edema apparent at E14
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immune system
• very few mature B cells are produced in irradiated mice reconstituted with mutant fetal liver cells
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• pro-B cell numbers were reduced
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• pre-B cells were nearly absent
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