Analysis Tools
skeleton
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• resorptive bone surfaces poorly defined with a broad fringe of demineralized matrix
• osteoclasts seeded onto dentine sections develop shallower pits with thicker layers of unprocessed residual matrix
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• diaphyseal cortical bone is less readily distinguished from subjacent trabecular bone
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• increased height of tibial growth plates
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• external form of bones is more gracile
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• dense trabeculation of bone marrow spaces in long bones particularly in regions of rapid longitudinal growth, distal femur and proximal tibia
• retention of cancellous bone in the shafts of long bones
• primary spongiosa of vertebrae is retained as well
• plates of bone more common than in controls where thinner rods are more typical
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osteopetrosis
(
J:50934
)
respiratory system
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• untreated mice with 20% thicker alveolar walls
• 1.5X greater collagen concentrations than in controls
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• more pronounced alveolar wall remodeling after bleomycin administration, increased 18% as opposed to 6% in controls
• collagen concentration increased 3 fold as opposed to 2 fold in controls
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immune system
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• resorptive bone surfaces poorly defined with a broad fringe of demineralized matrix
• osteoclasts seeded onto dentine sections develop shallower pits with thicker layers of unprocessed residual matrix
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hematopoietic system
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• resorptive bone surfaces poorly defined with a broad fringe of demineralized matrix
• osteoclasts seeded onto dentine sections develop shallower pits with thicker layers of unprocessed residual matrix
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homeostasis/metabolism
amyloidosis
(
J:116135
)
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• significantly larger amounts of amyloid deposited in the spleen
• amyloid deposits of smaller sized protein
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