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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctsstm1Eae
targeted mutation 1, Eileen A Elliot
MGI:2182132
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ctsstm1Eae/Ctsstm1Eae involves: C57BL/6 * DBA/1LacJ MGI:3845018
hm2
 		Ctsstm1Eae/Ctsstm1Eae NOD.D1-Ctsstm1Eae MGI:4420981
ht3
 		Ctsstm1Eae/Ctss+ NOD.D1-Ctsstm1Eae MGI:4420982


Genotype
MGI:3845018
hm1
Allelic
Composition		 Ctsstm1Eae/Ctsstm1Eae
Genetic
Background		 involves: C57BL/6 * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsstm1Eae mutation (1 available); any Ctss mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B lymphocyte antigen presentation ( J:53399 )
• reduced ability of B cells to present some soluble antigens to I-Ab restricted T cells
decreased susceptibility to induced arthritis ( J:53399 )
• resistant to collagen induced arthritis

skeleton
decreased susceptibility to induced arthritis ( J:53399 )
• resistant to collagen induced arthritis

hematopoietic system
abnormal B lymphocyte antigen presentation ( J:53399 )
• reduced ability of B cells to present some soluble antigens to I-Ab restricted T cells




Genotype
MGI:4420981
hm2
Allelic
Composition		 Ctsstm1Eae/Ctsstm1Eae
Genetic
Background		 NOD.D1-Ctsstm1Eae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsstm1Eae mutation (1 available); any Ctss mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
salivary gland inflammation ( J:153355 )
• sialadenitis is observed in both diabetic and non-diabetic mice at 6 months of age; average number of lesions observed is similar to number found in NOD mice
insulitis ( J:153355 )
• diabetic animals develop insulitis, however, lymphocytic infiltration is less than in diabetic NOD controls
decreased susceptibility to autoimmune diabetes ( J:153355 )
• hyperglycemia in females occurs at a lower percentage and later incidence than NOD controls

homeostasis/metabolism

endocrine/exocrine glands
salivary gland inflammation ( J:153355 )
• sialadenitis is observed in both diabetic and non-diabetic mice at 6 months of age; average number of lesions observed is similar to number found in NOD mice
insulitis ( J:153355 )
• diabetic animals develop insulitis, however, lymphocytic infiltration is less than in diabetic NOD controls

digestive/alimentary system
salivary gland inflammation ( J:153355 )
• sialadenitis is observed in both diabetic and non-diabetic mice at 6 months of age; average number of lesions observed is similar to number found in NOD mice




Genotype
MGI:4420982
ht3
Allelic
Composition		 Ctsstm1Eae/Ctss+
Genetic
Background		 NOD.D1-Ctsstm1Eae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsstm1Eae mutation (1 available); any Ctss mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
insulitis ( J:153355 )
• insulitis scores for diabetic animals are similar to scores for diabetic NOD controls

homeostasis/metabolism
hyperglycemia ( J:153355 )
• similar to NOD controls, 69% of female mice exhibit blood glucose levels of greater than 250 mg/dl between 4-6 months of age

endocrine/exocrine glands
insulitis ( J:153355 )
• insulitis scores for diabetic animals are similar to scores for diabetic NOD controls




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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory