About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctsstm1Eae
targeted mutation 1, Eileen A Elliot
MGI:2182132
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ctsstm1Eae/Ctsstm1Eae involves: C57BL/6 * DBA/1LacJ MGI:3845018
hm2
 		Ctsstm1Eae/Ctsstm1Eae NOD.D1-Ctsstm1Eae MGI:4420981
ht3
 		Ctsstm1Eae/Ctss+ NOD.D1-Ctsstm1Eae MGI:4420982


Genotype
MGI:3845018
hm1
Allelic
Composition		 Ctsstm1Eae/Ctsstm1Eae
Genetic
Background		 involves: C57BL/6 * DBA/1LacJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsstm1Eae mutation (1 available); any Ctss mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B lymphocyte antigen presentation ( J:53399 )
• reduced ability of B cells to present some soluble antigens to I-Ab restricted T cells
decreased susceptibility to induced arthritis ( J:53399 )
• resistant to collagen induced arthritis

skeleton
decreased susceptibility to induced arthritis ( J:53399 )
• resistant to collagen induced arthritis

hematopoietic system
abnormal B lymphocyte antigen presentation ( J:53399 )
• reduced ability of B cells to present some soluble antigens to I-Ab restricted T cells




Genotype
MGI:4420981
hm2
Allelic
Composition		 Ctsstm1Eae/Ctsstm1Eae
Genetic
Background		 NOD.D1-Ctsstm1Eae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsstm1Eae mutation (1 available); any Ctss mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
salivary gland inflammation ( J:153355 )
• sialadenitis is observed in both diabetic and non-diabetic mice at 6 months of age; average number of lesions observed is similar to number found in NOD mice
insulitis ( J:153355 )
• diabetic animals develop insulitis, however, lymphocytic infiltration is less than in diabetic NOD controls
decreased susceptibility to autoimmune diabetes ( J:153355 )
• hyperglycemia in females occurs at a lower percentage and later incidence than NOD controls

homeostasis/metabolism

endocrine/exocrine glands
salivary gland inflammation ( J:153355 )
• sialadenitis is observed in both diabetic and non-diabetic mice at 6 months of age; average number of lesions observed is similar to number found in NOD mice
insulitis ( J:153355 )
• diabetic animals develop insulitis, however, lymphocytic infiltration is less than in diabetic NOD controls

digestive/alimentary system
salivary gland inflammation ( J:153355 )
• sialadenitis is observed in both diabetic and non-diabetic mice at 6 months of age; average number of lesions observed is similar to number found in NOD mice




Genotype
MGI:4420982
ht3
Allelic
Composition		 Ctsstm1Eae/Ctss+
Genetic
Background		 NOD.D1-Ctsstm1Eae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsstm1Eae mutation (1 available); any Ctss mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
insulitis ( J:153355 )
• insulitis scores for diabetic animals are similar to scores for diabetic NOD controls

homeostasis/metabolism
hyperglycemia ( J:153355 )
• similar to NOD controls, 69% of female mice exhibit blood glucose levels of greater than 250 mg/dl between 4-6 months of age

endocrine/exocrine glands
insulitis ( J:153355 )
• insulitis scores for diabetic animals are similar to scores for diabetic NOD controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory