Phenotypes associated with this allele

• Allele Symbol: Ctsg^tm1Ley
• Allele Name: targeted mutation 1, Timothy J Ley
• Allele ID: MGI:2182136
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctsg^tm1Ley/Ctsg^tm1Ley	either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ)	MGI:3044739
hm2	Ctsg^tm1Ley/Ctsg^tm1Ley	Not Specified	MGI:3526662
ht3	Ctsg^tm1Ley/Ctsg^tm2.1(PML/RARA)Ley	involves: 129X1/SvJ * C57BL/6	MGI:3526661
cx4	Ctsg^tm1Ley/Ctsg^tm1Ley Elane^tm1Sds/Elane^tm1Sds	B6.129X1-Elane^tm1Sds Ctsg^tm1Ley	MGI:3785270
cx5	Ctsg^tm1Ley/Ctsg^tm1Ley Elane^tm1Sds/Elane^tm1Sds	involves: 129X1/SvJ	MGI:3785269

Genotype
MGI:3044739

hm1

• Allelic Composition: Ctsg^tm1Ley/Ctsg^tm1Ley
• Genetic Background: either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:59006 )

N • homozygotes showed normal hematopoietic development and normal blood clotting

N • neutrophils showed normal morphology, normal phagocytosis, and normal production of superoxide in response to in vitro stimuli

N • neutrophils displayed no defect in their ability to migrate towards a variety of chemotactic stimuli in vitro and in vivo

immune system

immune system phenotype ( J:59006 )

N • homozygotes were able to clear S. aureus, K. pneumoniae, and E. coli infections as efficiently as wild-type control mice

normal phenotype

no abnormal phenotype detected ( J:59006 )

• homozygotes were viable, fertile, overtly normal, and displayed normal growth and development

Genotype
MGI:3526662

hm2

• Allelic Composition: Ctsg^tm1Ley/Ctsg^tm1Ley
• Genetic Background: Not Specified

neoplasm

neoplasm ( J:84230 )

N • no acute myelogenous leukemia is seen

Genotype
MGI:3526661

ht3

• Allelic Composition: Ctsg^tm1Ley/Ctsg^{tm2.1(PML/RARA)Ley}
• Genetic Background: involves: 129X1/SvJ * C57BL/6

neoplasm

increased leukemia incidence ( J:84230 )

• compound heterozygotes develop an abrupt onset, rapidly fatal acute leukemia with age of onset and penetrance similar to Ctsg^tm2.1Ley heterozygotes

Genotype
MGI:3785270

cx4

• Allelic Composition: Ctsg^tm1Ley/Ctsg^tm1Ley; Elane^tm1Sds/Elane^tm1Sds
• Genetic Background: B6.129X1-Elane^tm1Sds Ctsg^tm1Ley

immune system

immune system phenotype ( J:131520 )

N • mice exhibit a normal response to infection with Sendai virus

Genotype
MGI:3785269

cx5

• Allelic Composition: Ctsg^tm1Ley/Ctsg^tm1Ley; Elane^tm1Sds/Elane^tm1Sds
• Genetic Background: involves: 129X1/SvJ

hematopoietic system

hematopoietic system phenotype ( J:131496 )

N • mice exhibit normal granulopoiesis

immune system

immune system phenotype ( J:131496 )

N • mice exhibit normal granulopoiesis