Phenotypes associated with this allele

• Allele Symbol: Ctsg^tm1.1Roes
• Allele Name: targeted mutation 1.1, Jurgen Roes
• Allele ID: MGI:2182170
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctsg^tm1.1Roes/Ctsg^tm1.1Roes	involves: 129P2/OlaHsd	MGI:3590143
cx2	Ctsg^tm1.1Roes/Ctsg^tm1.1Roes Elane^tm1(cre)Roes/Elane^tm1(cre)Roes	involves: 129P2/OlaHsd	MGI:3590145

Genotype
MGI:3590143

hm1

• Allelic Composition: Ctsg^tm1.1Roes/Ctsg^tm1.1Roes
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:77597 )

• median survival time is increased to 560 +/- 47 min compared to 435 +/- 8 min in wild-type mice

increased susceptibility to infection induced morbidity/mortality ( J:77597 )

• after infection with 500,000 A. fumigatus spores median survival time was only 13 +/- 4 days compared to wild-type mice which all survive

• 6 days after infection kidney fungal load (457 mean CFU) is higher than in wild-type (16 mean CFU) but lower than in Ctsg and Ela double homozygotes (1009 mean CFU)

immune system

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:77597 )

• median survival time is increased to 560 +/- 47 min compared to 435 +/- 8 min in wild-type mice

increased susceptibility to infection induced morbidity/mortality ( J:77597 )

• after infection with 500,000 A. fumigatus spores median survival time was only 13 +/- 4 days compared to wild-type mice which all survive

• 6 days after infection kidney fungal load (457 mean CFU) is higher than in wild-type (16 mean CFU) but lower than in Ctsg and Ela double homozygotes (1009 mean CFU)

Genotype
MGI:3590145

cx2

• Allelic Composition: Ctsg^tm1.1Roes/Ctsg^tm1.1Roes; Elane^tm1(cre)Roes/Elane^tm1(cre)Roes
• Genetic Background: involves: 129P2/OlaHsd

immune system

decreased susceptibility to endotoxin shock ( J:77597 )

• after injection of 100ng LPS along with D-galactosamine 54% of double homozygotes survive compared to only 9% of wild-type mice and median survival time is increased to 935 +/- 227 min compared to 435 +/- 8 min in wild-type mice

• LPS-induced increases in serum TNF, recruitment of neutrophils into the liver, and liver damage are all normal; however vascular and lung damage are reduced

increased susceptibility to fungal infection ( J:77597 )

• after infection with 500,000 A. fumigatus spores median survival time was only 10 +/- 3 days compared to wild-type mice which all survive

• infection with a lower concentration of spores, at which all single homozygotes survive, resulted in the death of 60% of double homozygotes

• 6 days after infection kidney fungal load is 1009 mean CFU much higher than wild-type (16 mean CFU) or either single homozygote