All Phenotypes Elane<tm1(cre)Roes> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Elane^tm1(cre)Roes
targeted mutation 1, Jurgen Roes
MGI:2182177

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Elane^tm1(cre)Roes/Elane^tm1(cre)Roes	involves: 129	MGI:3590144
hm2	Elane^tm1(cre)Roes/Elane^tm1(cre)Roes	involves: 129S6/SvEvTac	MGI:3804492
cn3	Csk^tm1Tara/Csk^tm2Tara Elane^tm1(cre)Roes/Elane⁺	involves: 129P2/OlaHsd * CB20 * C57BL/6	MGI:3050324
cx4	Ctsg^tm1.1Roes/Ctsg^tm1.1Roes Elane^tm1(cre)Roes/Elane^tm1(cre)Roes	involves: 129P2/OlaHsd	MGI:3590145

Allelic Composition	Elane^tm1(cre)Roes/Elane^tm1(cre)Roes
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1(cre)Roes mutation (5 available); any Elane mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:77597 )

• median survival time is increased to 477 +/- 88 min compared to 435 +/- 8 min in wild-type mice

increased susceptibility to infection induced morbidity/mortality ( J:77597 )

• after infection with 500,000 A. fumigatus spores only 60% of homozygotes survived more than 21 days compared to all wild-type mice surviving

• 6 days after infection kidney fungal load (304 mean CFU) is higher than in wild-type (16 mean CFU) but lower than in Ctsg and Ela double homozygotes (1009 mean CFU)

immune system

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:77597 )

• median survival time is increased to 477 +/- 88 min compared to 435 +/- 8 min in wild-type mice

increased susceptibility to infection induced morbidity/mortality ( J:77597 )

• after infection with 500,000 A. fumigatus spores only 60% of homozygotes survived more than 21 days compared to all wild-type mice surviving

• 6 days after infection kidney fungal load (304 mean CFU) is higher than in wild-type (16 mean CFU) but lower than in Ctsg and Ela double homozygotes (1009 mean CFU)

Allelic Composition	Elane^tm1(cre)Roes/Elane^tm1(cre)Roes
Genetic Background	involves: 129S6/SvEvTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elane^tm1(cre)Roes mutation (5 available); any Elane mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

impaired neutrophil recruitment ( J:137674 )

• in the reverse passive Arthus reaction model of immune complex-mediated inflammation neutrophil infiltration to sites of immune complex formation is marginally reduced

• reduction is not as severe as in mice homozygous for Ela2/Prtn3^tm1Deje

hematopoietic system

impaired neutrophil recruitment ( J:137674 )

• in the reverse passive Arthus reaction model of immune complex-mediated inflammation neutrophil infiltration to sites of immune complex formation is marginally reduced

• reduction is not as severe as in mice homozygous for Ela2/Prtn3^tm1Deje

Allelic Composition	Csk^tm1Tara/Csk^tm2Tara Elane^tm1(cre)Roes/Elane⁺
Genetic Background	involves: 129P2/OlaHsd * CB20 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csk^tm1Tara mutation (1 available); any Csk mutation (27 available)
Csk^tm2Tara mutation (0 available); any Csk mutation (27 available)
Elane^tm1(cre)Roes mutation (5 available); any Elane mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal myelopoiesis ( J:89716 )

• increased myelopoietic activity in bone marrow

abnormal granulocyte physiology ( J:89716 )

• increased cell adhesion

immune system

abnormal myelopoiesis ( J:89716 )

• increased myelopoietic activity in bone marrow

abnormal granulocyte physiology ( J:89716 )

• increased cell adhesion

increased acute inflammation ( J:89716 )

• inflammatory disorder in almost all mice after 6 weeks of age of CD4

• dermatitis-like symptomes

• inflammation of eyelids and ears

• acute pulmonary inflammation and perivascular accumulation of polymorphonuclear granulocytes

• granulocytic infiltration of dorsal deep dermis and subcutis of extremities

increased susceptibility to bacterial infection ( J:89716 )

• increased sensitivity to lipopolysaccharide

Allelic Composition	Ctsg^tm1.1Roes/Ctsg^tm1.1Roes Elane^tm1(cre)Roes/Elane^tm1(cre)Roes
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsg^tm1.1Roes mutation (5 available); any Ctsg mutation (13 available)
Elane^tm1(cre)Roes mutation (5 available); any Elane mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to endotoxin shock ( J:77597 )

• after injection of 100ng LPS along with D-galactosamine 54% of double homozygotes survive compared to only 9% of wild-type mice and median survival time is increased to 935 +/- 227 min compared to 435 +/- 8 min in wild-type mice

• LPS-induced increases in serum TNF, recruitment of neutrophils into the liver, and liver damage are all normal; however vascular and lung damage are reduced

increased susceptibility to fungal infection ( J:77597 )

• after infection with 500,000 A. fumigatus spores median survival time was only 10 +/- 3 days compared to wild-type mice which all survive

• infection with a lower concentration of spores, at which all single homozygotes survive, resulted in the death of 60% of double homozygotes

• 6 days after infection kidney fungal load is 1009 mean CFU much higher than wild-type (16 mean CFU) or either single homozygote

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