All Phenotypes Lta/Tnf<tm1Eug> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	B6.129-Lta/Tnf^tm1Eug	MGI:4867499
hm2	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	involves: 129	MGI:3768383
hm3	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	involves: 129 * C57BL/6J	MGI:4867649
hm4	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	involves: 129/Sv * C57BL/6	MGI:4867497

Allelic Composition	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug
Genetic Background	B6.129-Lta/Tnf^tm1Eug

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnf^tm1Eug mutation (0 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:115034 )

• most S. aureus-infected mice die unlike similarly treated wild-type mice

immune system

impaired macrophage phagocytosis ( J:115034 )

• in S.aureus-infected mice

decreased IgG1 level ( J:115034 )

• in S.aureus-infected mice

decreased IgG2a level ( J:115034 )

• in S.aureus-infected mice

decreased IgG3 level ( J:115034 )

• in S.aureus-infected mice

increased IgM level ( J:115034 )

• in S.aureus-infected mice

decreased circulating interferon-gamma level ( J:115034 )

• 28 days after S. aureus infection

decreased interferon-gamma secretion ( J:115034 )

• from spleen cells of S. aureus-infected mice

decreased susceptibility to induced arthritis ( J:115034 )

• S. aureus-infected mice exhibit decreased septic arthritis compared with similarly treated wild-type mice

increased susceptibility to bacterial infection ( J:115034 )

• Staphylococcus aureus-infected mice exhibit greater weight loss, increased mortality, reduced bacterial clearance, decreased IFN-gamma production, decreased septic arthritis, increased IgM serum levels, and decreased antigen-specific IgG serum levels compared with similarly treated wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:115034 )

• most S. aureus-infected mice die unlike similarly treated wild-type mice

skeleton

decreased susceptibility to induced arthritis ( J:115034 )

• S. aureus-infected mice exhibit decreased septic arthritis compared with similarly treated wild-type mice

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:115034 )

• 28 days after S. aureus infection

behavior/neurological

abnormal sleep pattern ( J:103266 )

• mice exhibit reduced rapid eye movement (REM) sleep episode frequency compared with wild-type mice

• mice exhibit higher absolute electroencephalogram (EEG) power density non-REM sleep within the slow-wave range compared with wild-type mice

• after sleep deprivation, mice exhibit a greater increase in fast 'slow waves' compared with wild-type mice

• however, a decrease in non-REM sleep episode frequency is compensated by extension of non-REM sleep episode duration

hematopoietic system

impaired macrophage phagocytosis ( J:115034 )

• in S.aureus-infected mice

decreased IgG1 level ( J:115034 )

• in S.aureus-infected mice

decreased IgG2a level ( J:115034 )

• in S.aureus-infected mice

decreased IgG3 level ( J:115034 )

• in S.aureus-infected mice

increased IgM level ( J:115034 )

• in S.aureus-infected mice

cellular

impaired macrophage phagocytosis ( J:115034 )

• in S.aureus-infected mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:31129 )

• mice survive doses of LPS that are 100 times as much as the dose that would kill a wild-type mouse

increased susceptibility to induced morbidity/mortality ( J:31129 )

• mice cannot control a dose Listeria monocytogenes that is tolerated by wild-type mice and eventually die from listeriosis with high liver and spleen titers and large necrotic lesions with boundaries of heavily infected hepatocytes

immune system

decreased T cell number ( J:31129 )

• CD3+ T cells are decreased (25%+/-3% compared to 45%+/-3% in wild-type mice)

• peripheral T cells are decreased 2-fold compared to wild-type

increased leukocyte cell number ( J:31129 )

• leukocyte cell number is increased 4-fold compared to wild-type

increased B cell number ( J:31129 )

• 65%+/-4% B220+ B cells compared to 44%+/-2% in wild-type mice

• peripheral B cells are increased 6-fold compared to wild-type

abnormal spleen morphology ( J:31129 )

• spleen lymphocyte composition and micro-architecture are altered

• the T cell zones are lost and the marginal zone is ill-defined

abnormal spleen marginal zone morphology ( J:31129 )

• the marginal zone is ill-defined

absent Peyer's patches ( J:31129 )

absent lymph nodes ( J:31129 )

abnormal humoral immune response ( J:31129 )

• mice are unable to mount a primary IgG response to sheep red blood cells

decreased IgA level ( J:31129 )

increased susceptibility to bacterial infection ( J:31129 )

increased susceptibility to Poxviridae infection ( J:31129 )

• response to VV-WR infection is slightly reduced

increased susceptibility to Riboviria infection ( J:31129 )

• response to LCMV-ARM is strongly reduced

• when footpads are infected with LCMV-ARM or LCMV-WE they fail to swell as in wild-type mice

hematopoietic system

decreased T cell number ( J:31129 )

• CD3+ T cells are decreased (25%+/-3% compared to 45%+/-3% in wild-type mice)

• peripheral T cells are decreased 2-fold compared to wild-type

increased leukocyte cell number ( J:31129 )

• leukocyte cell number is increased 4-fold compared to wild-type

increased B cell number ( J:31129 )

• 65%+/-4% B220+ B cells compared to 44%+/-2% in wild-type mice

• peripheral B cells are increased 6-fold compared to wild-type

abnormal spleen morphology ( J:31129 )

• spleen lymphocyte composition and micro-architecture are altered

• the T cell zones are lost and the marginal zone is ill-defined

abnormal spleen marginal zone morphology ( J:31129 )

• the marginal zone is ill-defined

decreased IgA level ( J:31129 )

Allelic Composition	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnf^tm1Eug mutation (0 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased heart weight ( J:112797 )

• when fed a high cholesterol diet

increased body mass index ( J:112797 )

• when fed a high cholesterol diet

increased body weight ( J:112797 )

• whether fed standard chow or a high cholesterol diet

increased body length ( J:112797 )

• when fed a high cholesterol diet

increased susceptibility to diet-induced obesity ( J:112797 )

• when fed a high cholesterol diet

enlarged liver ( J:112797 )

• after 12 weeks on a high cholesterol diet

increased liver weight ( J:112797 )

• after 12 weeks on a high cholesterol diet

increased spleen weight ( J:112797 )

• when fed a high cholesterol diet

liver/biliary system

enlarged liver ( J:112797 )

• after 12 weeks on a high cholesterol diet

increased liver weight ( J:112797 )

• after 12 weeks on a high cholesterol diet

hepatic steatosis ( J:112797 )

• after 12 weeks on a high cholesterol diet

skeleton

long tibia ( J:112797 )

• when fed a high cholesterol diet

cardiovascular system

increased heart weight ( J:112797 )

• when fed a high cholesterol diet

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:112797 )

• when fed a high cholesterol diet

immune system

increased spleen weight ( J:112797 )

• when fed a high cholesterol diet

limbs/digits/tail

long tibia ( J:112797 )

• when fed a high cholesterol diet

hematopoietic system

increased spleen weight ( J:112797 )

• when fed a high cholesterol diet

Allelic Composition	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnf^tm1Eug mutation (0 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:61314 )

• following traumatic brain injury, more mice die than similarly treated wild-type mice

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )

• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, and reduced demyelination but increased number of inflammatory foci compared with similarly treated wild-type mice

decreased susceptibility to parasitic infection ( J:37696 )

• mice treated with Plasmodium berghei ANKA (PbA)-infected erythrocytes fail to develop cerebral malaria or vascular leakiness unlike similarly treated wild-type mice

• however, mice treated with PbA-infected with erythrocytes exhibit weight loss, anemia, high parasitemia, and die between 15 and 20 days post-infection

homeostasis/metabolism

increased susceptibility to injury ( J:61314 )

• following traumatic brain injury, more mice die than similarly treated wild-type mice

• however, traumatic brain injury-induced blood brain barrier disfunction and accumulation of polymononuclear leukocytes is normal

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