All Phenotypes Lta/Tnf<tm1Eug> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	B6.129-Lta/Tnf^tm1Eug	MGI:4867499
hm2	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	involves: 129	MGI:3768383
hm3	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	involves: 129 * C57BL/6J	MGI:4867649
hm4	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug	involves: 129/Sv * C57BL/6	MGI:4867497

Allelic Composition	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug
Genetic Background	B6.129-Lta/Tnf^tm1Eug

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnf^tm1Eug mutation (0 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:115034 )

• most S. aureus-infected mice die unlike similarly treated wild-type mice

immune system

impaired macrophage phagocytosis ( J:115034 )

• in S.aureus-infected mice

decreased IgG1 level ( J:115034 )

• in S.aureus-infected mice

decreased IgG2a level ( J:115034 )

• in S.aureus-infected mice

decreased IgG3 level ( J:115034 )

• in S.aureus-infected mice

increased IgM level ( J:115034 )

• in S.aureus-infected mice

decreased circulating interferon-gamma level ( J:115034 )

• 28 days after S. aureus infection

decreased interferon-gamma secretion ( J:115034 )

• from spleen cells of S. aureus-infected mice

decreased susceptibility to induced arthritis ( J:115034 )

• S. aureus-infected mice exhibit decreased septic arthritis compared with similarly treated wild-type mice

increased susceptibility to bacterial infection ( J:115034 )

• Staphylococcus aureus-infected mice exhibit greater weight loss, increased mortality, reduced bacterial clearance, decreased IFN-gamma production, decreased septic arthritis, increased IgM serum levels, and decreased antigen-specific IgG serum levels compared with similarly treated wild-type mice

increased susceptibility to bacterial infection induced morbidity/mortality ( J:115034 )

• most S. aureus-infected mice die unlike similarly treated wild-type mice

skeleton

decreased susceptibility to induced arthritis ( J:115034 )

• S. aureus-infected mice exhibit decreased septic arthritis compared with similarly treated wild-type mice

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:115034 )

• 28 days after S. aureus infection

behavior/neurological

abnormal sleep pattern ( J:103266 )

• mice exhibit reduced rapid eye movement (REM) sleep episode frequency compared with wild-type mice

• mice exhibit higher absolute electroencephalogram (EEG) power density non-REM sleep within the slow-wave range compared with wild-type mice

• after sleep deprivation, mice exhibit a greater increase in fast 'slow waves' compared with wild-type mice

• however, a decrease in non-REM sleep episode frequency is compensated by extension of non-REM sleep episode duration

hematopoietic system

impaired macrophage phagocytosis ( J:115034 )

• in S.aureus-infected mice

decreased IgG1 level ( J:115034 )

• in S.aureus-infected mice

decreased IgG2a level ( J:115034 )

• in S.aureus-infected mice

decreased IgG3 level ( J:115034 )

• in S.aureus-infected mice

increased IgM level ( J:115034 )

• in S.aureus-infected mice

cellular

impaired macrophage phagocytosis ( J:115034 )

• in S.aureus-infected mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

decreased susceptibility to induced morbidity/mortality ( J:31129 )

• mice survive doses of LPS that are 100 times as much as the dose that would kill a wild-type mouse

increased susceptibility to induced morbidity/mortality ( J:31129 )

• mice cannot control a dose Listeria monocytogenes that is tolerated by wild-type mice and eventually die from listeriosis with high liver and spleen titers and large necrotic lesions with boundaries of heavily infected hepatocytes

immune system

decreased T cell number ( J:31129 )

• CD3+ T cells are decreased (25%+/-3% compared to 45%+/-3% in wild-type mice)

• peripheral T cells are decreased 2-fold compared to wild-type

increased leukocyte cell number ( J:31129 )

• leukocyte cell number is increased 4-fold compared to wild-type

increased B cell number ( J:31129 )

• 65%+/-4% B220+ B cells compared to 44%+/-2% in wild-type mice

• peripheral B cells are increased 6-fold compared to wild-type

abnormal spleen morphology ( J:31129 )

• spleen lymphocyte composition and micro-architecture are altered

• the T cell zones are lost and the marginal zone is ill-defined

abnormal spleen marginal zone morphology ( J:31129 )

• the marginal zone is ill-defined

absent Peyer's patches ( J:31129 )

absent lymph nodes ( J:31129 )

abnormal humoral immune response ( J:31129 )

• mice are unable to mount a primary IgG response to sheep red blood cells

decreased IgA level ( J:31129 )

increased susceptibility to bacterial infection ( J:31129 )

increased susceptibility to Poxviridae infection ( J:31129 )

• response to VV-WR infection is slightly reduced

increased susceptibility to Riboviria infection ( J:31129 )

• response to LCMV-ARM is strongly reduced

• when footpads are infected with LCMV-ARM or LCMV-WE they fail to swell as in wild-type mice

hematopoietic system

decreased T cell number ( J:31129 )

• CD3+ T cells are decreased (25%+/-3% compared to 45%+/-3% in wild-type mice)

• peripheral T cells are decreased 2-fold compared to wild-type

increased leukocyte cell number ( J:31129 )

• leukocyte cell number is increased 4-fold compared to wild-type

increased B cell number ( J:31129 )

• 65%+/-4% B220+ B cells compared to 44%+/-2% in wild-type mice

• peripheral B cells are increased 6-fold compared to wild-type

abnormal spleen morphology ( J:31129 )

• spleen lymphocyte composition and micro-architecture are altered

• the T cell zones are lost and the marginal zone is ill-defined

abnormal spleen marginal zone morphology ( J:31129 )

• the marginal zone is ill-defined

decreased IgA level ( J:31129 )

Allelic Composition	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug
Genetic Background	involves: 129 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnf^tm1Eug mutation (0 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased heart weight ( J:112797 )

• when fed a high cholesterol diet

increased body mass index ( J:112797 )

• when fed a high cholesterol diet

increased body weight ( J:112797 )

• whether fed standard chow or a high cholesterol diet

increased body length ( J:112797 )

• when fed a high cholesterol diet

increased susceptibility to diet-induced obesity ( J:112797 )

• when fed a high cholesterol diet

enlarged liver ( J:112797 )

• after 12 weeks on a high cholesterol diet

increased liver weight ( J:112797 )

• after 12 weeks on a high cholesterol diet

increased spleen weight ( J:112797 )

• when fed a high cholesterol diet

liver/biliary system

enlarged liver ( J:112797 )

• after 12 weeks on a high cholesterol diet

increased liver weight ( J:112797 )

• after 12 weeks on a high cholesterol diet

hepatic steatosis ( J:112797 )

• after 12 weeks on a high cholesterol diet

skeleton

long tibia ( J:112797 )

• when fed a high cholesterol diet

cardiovascular system

increased heart weight ( J:112797 )

• when fed a high cholesterol diet

homeostasis/metabolism

increased susceptibility to diet-induced obesity ( J:112797 )

• when fed a high cholesterol diet

immune system

increased spleen weight ( J:112797 )

• when fed a high cholesterol diet

limbs/digits/tail

long tibia ( J:112797 )

• when fed a high cholesterol diet

hematopoietic system

increased spleen weight ( J:112797 )

• when fed a high cholesterol diet

Allelic Composition	Lta/Tnf^tm1Eug/Lta/Tnf^tm1Eug
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lta/Tnf^tm1Eug mutation (0 available); any Tnf mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:61314 )

• following traumatic brain injury, more mice die than similarly treated wild-type mice

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:115225 )

• following treatment with MOG, mice exhibit delayed onset, decreased severity of disease, and reduced demyelination but increased number of inflammatory foci compared with similarly treated wild-type mice

decreased susceptibility to parasitic infection ( J:37696 )

• mice treated with Plasmodium berghei ANKA (PbA)-infected erythrocytes fail to develop cerebral malaria or vascular leakiness unlike similarly treated wild-type mice

• however, mice treated with PbA-infected with erythrocytes exhibit weight loss, anemia, high parasitemia, and die between 15 and 20 days post-infection

homeostasis/metabolism

increased susceptibility to injury ( J:61314 )

• however, traumatic brain injury-induced blood brain barrier disfunction and accumulation of polymononuclear leukocytes is normal

• following traumatic brain injury, more mice die than similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24