Analysis Tools
mortality/aging
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• all male and female mutants survive after being given a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (200 ug/kg), while all male but no female wild-type mice died by 22 - 26 days after exposure
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homeostasis/metabolism
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• in benzo[a]pyrene (BaP)-treated mice
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• in benzo[a]pyrene (BaP)-treated mice
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• all male and female mutants survive after being given a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) (200 ug/kg), while all male but no female wild-type mice died by 22 - 26 days after exposure
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• TCDD-induced wasting is not seen in homozygotes while thymic involution, decrease in spleen weight, increase in hepatocyte size, increase in hepatic uroporphyrin content, and increase in intra-hepatocyte and total liver lipid are less severe than in TCDD treated wild-type mice
• the ratio of TCDD-induced extrahepatic versus hepatic damage (measured by the ratio of plasma AST to ALT) is less than 1 in homozygotes and greater than 1 in wild-type mice
• however, the distribution of TCDD (liver/adipose ratio) is similar to wild-type mice
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• after dioxin treatment (64 ug/kg) mice show increased levels of liver inflammation and serum ALT
(J:147150)
• however, levels of hydropic degeneration are similar to controls
(J:147150)
• benzo[a]pyrene (BaP)-treated mice exhibit moderate toxicity (weight loss, decreased spleen and thymus weight, increased liver weight, increased serum alanine and aspartate transaminase levels, decreased hematocrit and hemoglobin, increased methemoglobin, increased neutrophils, and decreased lymphocytes) compared with similarly treated wild-type mice
(J:163973)
• BaP-toxicity is more severe than in similarly treated Cyp1a1tm4.1Dwn homozygotes
(J:163973)
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• benzo[a]pyrene (BaP)-treated mice exhibit an 25-fold increase in BaP serum levels compared to wild-type mice
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hematopoietic system
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• in benzo[a]pyrene (BaP)-treated mice
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• in benzo[a]pyrene (BaP)-treated mice
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• benzo[a]pyrene (BaP)-treated mice exhibit an increase in methemoglobin compared with similarly treated wild-type mice
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• in benzo[a]pyrene (BaP)-treated mice
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• in benzo[a]pyrene (BaP)-treated mice
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• in benzo[a]pyrene (BaP)-treated mice
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• in benzo[a]pyrene (BaP)-treated mice
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liver/biliary system
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• in benzo[a]pyrene (BaP)-treated mice
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• basal and TCDD-induced NADPH-dependent H2O2 production in hepatic microsomes are decreased compared to wild-type mice
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growth/size/body
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• in benzo[a]pyrene (BaP)-treated mice
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• in benzo[a]pyrene (BaP)-treated mice
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immune system
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• in benzo[a]pyrene (BaP)-treated mice
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• in benzo[a]pyrene (BaP)-treated mice
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• in benzo[a]pyrene (BaP)-treated mice
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• in benzo[a]pyrene (BaP)-treated mice
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endocrine/exocrine glands
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• in benzo[a]pyrene (BaP)-treated mice
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