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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Cysltr1tm1Ykn
targeted mutation 1, Yoshihide Kanaoka
MGI:2182326
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Cysltr1tm1Ykn/Cysltr1tm1Ykn C.B6-Cysltr1tm1Ykn MGI:5316009
hm2
 		Cysltr1tm1Ykn/Cysltr1tm1Ykn involves: C57BL/6 MGI:3694668
cx3
 		Cysltr1tm1Ykn/Cysltr1tm1Ykn
Cysltr2tm1Ykn/Cysltr2tm1Ykn 		involves: BALB/c * C57BL/6 MGI:5532485
cx4
 		Cysltr1tm1Ykn/Cysltr1tm1Ykn
Cysltr2tm1Ykn/Cysltr2tm1Ykn
Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg 		involves: BALB/c * C57BL/6 * C57BL/6NTac MGI:5532486


Genotype
MGI:5316009
hm1
Allelic
Composition		 Cysltr1tm1Ykn/Cysltr1tm1Ykn
Genetic
Background		 C.B6-Cysltr1tm1Ykn
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cysltr1tm1Ykn mutation (2 available); any Cysltr1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:182213 )
N
• mutants exhibit normal epidermal and dermal thickening, collagen deposition, and dermal infiltration by CD4+ cells and eosinophils in OVA-sensitized skin compared to wild-type mice




Genotype
MGI:3694668
hm2
Allelic
Composition		 Cysltr1tm1Ykn/Cysltr1tm1Ykn
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cysltr1tm1Ykn mutation (2 available); any Cysltr1 mutation (11 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to type I hypersensitivity reaction ( J:77087 )
• passive cutaneous anaphylaxis responses are significantly reduced
respiratory system inflammation ( J:88647 )
• exaggerated pulmonary inflammation compared to controls 7 days after bleomycin injection
• thickened alveolar septa after bleomycin injection
• increased extra cellular matrix after bleomycin injection
• increased clusters of monocytes/macrophage, giant cells, neutrophiles, eosinophiles after bleomycin injection
• increased cysteinyl leukotrienes in broncheoalveolar lavage fluid after bleomycin injection

cellular
abnormal cell physiology ( J:77087 )
• no intracellular calcium flux induced in macrophage after stimulation with leukotriene D4 or C4

cardiovascular system
decreased vascular permeability ( J:77087 )
• plasma protein extravasation into the peritoneum in response to zymosan A is repressed

respiratory system
respiratory system inflammation ( J:88647 )
• exaggerated pulmonary inflammation compared to controls 7 days after bleomycin injection
• thickened alveolar septa after bleomycin injection
• increased extra cellular matrix after bleomycin injection
• increased clusters of monocytes/macrophage, giant cells, neutrophiles, eosinophiles after bleomycin injection
• increased cysteinyl leukotrienes in broncheoalveolar lavage fluid after bleomycin injection




Genotype
MGI:5532485
cx3
Allelic
Composition		 Cysltr1tm1Ykn/Cysltr1tm1Ykn
Cysltr2tm1Ykn/Cysltr2tm1Ykn
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cysltr1tm1Ykn mutation (2 available); any Cysltr1 mutation (11 available)
Cysltr2tm1Ykn mutation (2 available); any Cysltr2 mutation (34 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:198383 )
• at high doses, mice exhibit enhanced leukotriene E4 ligand (LTE4)-induced ear edema compared with wild-type mice
• at high doses, mice exhibit slightly reduced leukotriene C4 ligand (LTC4)-induced ear edema compared with wild-type mice




Genotype
MGI:5532486
cx4
Allelic
Composition		 Cysltr1tm1Ykn/Cysltr1tm1Ykn
Cysltr2tm1Ykn/Cysltr2tm1Ykn
Oxgr1tm1(KOMP)Vlcg/Oxgr1tm1(KOMP)Vlcg
Genetic
Background		 involves: BALB/c * C57BL/6 * C57BL/6NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cysltr1tm1Ykn mutation (2 available); any Cysltr1 mutation (11 available)
Cysltr2tm1Ykn mutation (2 available); any Cysltr2 mutation (34 available)
Oxgr1tm1(KOMP)Vlcg mutation (1 available); any Oxgr1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immune system physiology ( J:198383 )
• at high doses, mice exhibit reduced leukotriene E4 ligand (LTE4) or leukotriene C4 ligand (LTC4)-induced ear edema compared with wild-type mice
• at low and intermediate doses, mice fail to exhibit leukotriene E4 ligand (LTE4)-, leukotriene C4 ligand (LTC4)- or leukotriene D4 (LTD4)-induced ear edema unlike wild-type mice




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory