Phenotypes associated with this allele

• Allele Symbol: Cyp7b1^tm1Lth
• Allele Name: targeted mutation 1, Richard Lathe
• Allele ID: MGI:2182328
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp7b1^tm1Lth/Cyp7b1^tm1Lth	involves: 129P2/OlaHsd * C57BL/6	MGI:3765072

Genotype
MGI:3765072

hm1

• Allelic Composition: Cyp7b1^tm1Lth/Cyp7b1^tm1Lth
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal mammary gland development ( J:96829 )

♀ • early onset of growth of mammary gland with much more ductal growth

premature ovarian failure ( J:96829 )

♀ • premature exhaustion of ovarian function

mortality/aging

premature ovarian failure ( J:96829 )

♀ • premature exhaustion of ovarian function

reproductive system

premature ovarian failure ( J:96829 )

♀ • premature exhaustion of ovarian function

abnormal uterus development ( J:96829 )

♀ • early onset of growth of uterine glands

uterus atrophy ( J:96829 )

♀ • by 15 month of age, the uterine glands were prematurely sclerotic and atrophic and the mammary glands showed signs of atrophy

early sexual maturation ( J:96829 )

♀ • precocious puberty in females

abnormal estrous cycle ( J:96829 )

♀ • mutant females begin estrus cycling 2 days earlier than their wild-type littermates

absent estrous cycle ( J:96829 )

♀ • at 15 month of age, estrous cycling has prematurely terminated in mutant females

integument

abnormal mammary gland development ( J:96829 )

♀ • early onset of growth of mammary gland with much more ductal growth