Phenotypes associated with this allele

• Allele Symbol: Cyp1a2^tm1Dwn
• Allele Name: targeted mutation 1, Daniel W Nebert
• Allele ID: MGI:2182351
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cyp1a2^tm1Dwn/Cyp1a2^tm1Dwn	B6.129P2-Cyp1a2^tm1Dwn	MGI:3656134
hm2	Cyp1a2^tm1Dwn/Cyp1a2^tm1Dwn	either: (involves: 129P2/OlaHsd * Black Swiss) or (involves: 129P2/OlaHsd * CF-1)	MGI:3656135

Genotype
MGI:3656134

hm1

• Allelic Composition: Cyp1a2^tm1Dwn/Cyp1a2^tm1Dwn
• Genetic Background: B6.129P2-Cyp1a2^tm1Dwn

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Dioxin-induced hepatic injury in Cyp1a1^tm1.1Dwn/Cyp1a1^tm1.1Dwn and Cyp1a2^tm1Dwn/Cyp1a2^tm1Dwn mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:147150 )

• after dioxin treatment (64 ug/kg) mice show increased levels of liver inflammation and serum ALT but lower levels of hydropic degeneration

decreased physiological sensitivity to xenobiotic ( J:81115 , J:97596 )

• injection of hexachlorobenzene and Fe dextran followed by water born exposure to 5-aminolevulinate fails to increase urinary or hepatic uroporphyrin levels unlike in wild-type mice (J:81115)

• however, levels of nonheme iron in the liver are similar to wild-type mice (J:81115)

• dietary PCB exposure combined with a subcutaneous dose of iron fails to induce hepatic pophyria after 7 weeks unlike in wild-type mice (J:97596)

• after 57 weeks of continued dietary PCB exposure homozygotes fail to develop preneoplastic foci or hepatic adenomas unlike wild-type mice; however other liver changes (cellular hypertrophy, focal inflammation, and bile duct proliferation) are similar to wild type mice (J:97596)

decreased incidence of tumors by chemical induction ( J:97596 )

• after 57 weeks of continued dietary PCB exposure homozygotes fail to develop preneoplastic foci or hepatic adenomas unlike wild-type mice

abnormal xenobiotic pharmacokinetics ( J:89337 )

• the distribution of TCDD (liver/adipose ratio) is about 15 times less than in wild-type mice

liver/biliary system

abnormal liver physiology ( J:88957 )

• basal and TCDD-induced NADPH-dependent H2O2 production in hepatic microsomes are increased compared to wild-type mice

neoplasm

decreased incidence of tumors by chemical induction ( J:97596 )

• after 57 weeks of continued dietary PCB exposure homozygotes fail to develop preneoplastic foci or hepatic adenomas unlike wild-type mice

Genotype
MGI:3656135

hm2

• Allelic Composition: Cyp1a2^tm1Dwn/Cyp1a2^tm1Dwn
• Genetic Background: either: (involves: 129P2/OlaHsd * Black Swiss) or (involves: 129P2/OlaHsd * CF-1)

behavior/neurological

enhanced behavioral response to xenobiotic ( J:31730 )

• remain paralyzed at least 9 times longer than wild-type mice after treatment with zoxazolamine and no difference in the length of paralysis is seen with or without beta-naphthoflavone pretreatment

• in the absence of treatment no morphological or developmental abnormalities are detected