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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ggt5tm1Mwl
targeted mutation 1, Michael W Lieberman
MGI:2182354
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ggt5tm1Mwl/Ggt5tm1Mwl involves: 129S7/SvEvBrd * C57BL/6J MGI:3640352
cx2
 		Ggt1tm1Zuk/Ggt1tm1Zuk
Ggt5tm1Mwl/Ggt5tm1Mwl 		involves: 129S7/SvEvBrd * C57BL/6J MGI:3640353


Genotype
MGI:3640352
hm1
Allelic
Composition		 Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggt5tm1Mwl mutation (0 available); any Ggt5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:77691 )
N
• grossly normal and fertile
• survive at least 1 year

immune system
decreased acute inflammation ( J:77691 )
• reduced accumulation of neutrophiles during zymosan A induced peritonitis




Genotype
MGI:3640353
cx2
Allelic
Composition		 Ggt1tm1Zuk/Ggt1tm1Zuk
Ggt5tm1Mwl/Ggt5tm1Mwl
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggt1tm1Zuk mutation (0 available); any Ggt1 mutation (52 available)
Ggt5tm1Mwl mutation (0 available); any Ggt5 mutation (27 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:77691 )
• fail to thrive
• 70% die within 4 weeks of life
• lethality rescued if N-acetyl cysteine (NAC) provided in drinking water from birth but not if administration delayed until after weaning
• 84% of NAC treated mice survive to 28 days
• about 50% of NAC treated mice survive to 12 weeks

growth/size/body
postnatal growth retardation ( J:77691 )
• rescued by NAC administration in drinking water starting at birth
• weight of NAC treated mice at 8-12 weeks of age 90% of control weight

reproductive system
abnormal sexual maturation ( J:77691 )
• sexual immaturity
reduced fertility ( J:77691 )
• in NAC treated mice of both sexes when mated to wild-type partners

vision/eye
cataract ( J:77691 )
• bilateral
• NAC treatment partially prevents cataract formation

pigmentation
abnormal coat/hair pigmentation ( J:77691 )
• gray coat color
• more normal coat color in NAC treated mice

integument
abnormal coat/hair pigmentation ( J:77691 )
• gray coat color
• more normal coat color in NAC treated mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory