Phenotypes associated with this allele

• Allele Symbol: Mnx1^tm1Tmj
• Allele Name: targeted mutation 1, Thomas M Jessell
• Allele ID: MGI:2182358
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mnx1^tm1Tmj/Mnx1^tm1Tmj	involves: 129S1/Sv	MGI:3844956

Genotype
MGI:3844956

hm1

• Allelic Composition: Mnx1^tm1Tmj/Mnx1^tm1Tmj
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:57340 )

• homozygotes born at normal frequency

• die shortly after birth

respiratory system

primary atelectasis ( J:57340 )

• lungs fail to inflate at birth

nervous system

nervous system phenotype ( J:57340 )

N • fore- and hindlimb innervation is normal

abnormal motor neuron morphology ( J:57340 )

• at E10-E11, about 5% of motor neuron cell bodies are found in the ventral root rather than the spinal cord

• motor neurons of the hypoglossal motor nucleus are abnormally dispersed

• median and lateral motor columns in the cervical and lumbar regions of the spinal cord are less defined

abnormal axon morphology ( J:57340 )

• disorganized pattern of nerve branching at the axial muscle branch point and in the plexi at the base of the fore- and hindlimbs

• motor axons to the limbs are dispersed and defasciculated

• major motor axons to the limbs are present despite disorganization

muscle

thin diaphragm muscle ( J:57340 )

• acetylcholine receptor clusters are more dispersed and smaller than normal

• acetylcholine receptor clusters are often not associated with nerve terminals

digestive/alimentary system

abnormal duodenum morphology ( J:57317 )

• expanded at E17.5

• gastrointestinal tract otherwise normal

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:57317 )

• normal islet structure is disrupted in the ventral pancreas at E17.5

decreased pancreatic beta cell number ( J:57317 )

• 20% reduction in insulin positive cells in the ventral pancreas at E17.5

decreased pancreatic delta cell number ( J:57317 )

• three fold increase in somatostatin positive cells in the ventral pancreas at E17.5

abnormal pancreas development ( J:57317 )

• evagination of the dorsal pancreatic bud fails to take place