Phenotypes associated with this allele

• Allele Symbol: Mnx1^tm2Tmj
• Allele Name: targeted mutation 2, Thomas M Jessell
• Allele ID: MGI:2182361
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mnx1^tm2Tmj/Mnx1^tm2Tmj	involves: 129S1/Sv	MGI:3844958

Genotype
MGI:3844958

hm1

• Allelic Composition: Mnx1^tm2Tmj/Mnx1^tm2Tmj
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:57340 )

• die shortly after birth

• homozygotes born at normal frequency

respiratory system

primary atelectasis ( J:57340 )

• lungs fail to inflate at birth

nervous system

nervous system phenotype ( J:57340 )

N • fore- and hindlimb innervation is normal

abnormal motor neuron morphology ( J:57340 )

• at E10-E11, about 5% of motor neuron cell bodies are found in the ventral root rather than the spinal cord

• motor neurons of the hypoglossal motor nucleus are abnormally dispersed

• median and lateral motor columns in the cervical and lumbar regions of the spinal cord are less defined

abnormal axon morphology ( J:57340 )

• disorganized pattern of nerve branching at the axial muscle branch point and in the plexi at the base of the fore- and hindlimbs

• motor axons to the limbs are dispersed and defasciculated

• major motor axons to the limbs are present despite disorganization

• highly variable axon misdirection, from completely normal to absent axons

abnormal hypoglossal nerve morphology ( J:57340 )

• highly variable axon misdirection, from completely normal to absent axons

muscle

thin diaphragm muscle ( J:57340 )

• acetylcholine receptor clusters are more dispersed and smaller than normal

• acetylcholine receptor clusters are often not associated with nerve terminals