All Phenotypes Tacr1<tm1Sph> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tacr1^tm1Sph
targeted mutation 1, Stephen P Hunt
MGI:2182395

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tacr1^tm1Sph/Tacr1^tm1Sph	involves: 129 * C57BL/6	MGI:3621187
hm2	Tacr1^tm1Sph/Tacr1^tm1Sph	involves: 129P2/OlaHsd	MGI:4821001
hm3	Tacr1^tm1Sph/Tacr1^tm1Sph	involves: 129P2/OlaHsd * C57BL/6	MGI:3619726
hm4	Tacr1^tm1Sph/Tacr1^tm1Sph	involves: 129P2/OlaHsd * C57BL/6 * MF1	MGI:3619727

Allelic Composition	Tacr1^tm1Sph/Tacr1^tm1Sph
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1^tm1Sph mutation (2 available); any Tacr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal nervous system physiology ( J:106301 )

• superfusion of the medulla and spinal cord of P1 nulls with aCSF containing SP did not change the respiratory frequency or amplitude of motor outpur significantly, whereas in wild-type preparations, the respiratory frequency increased to 147.9% of conrol

Allelic Composition	Tacr1^tm1Sph/Tacr1^tm1Sph
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1^tm1Sph mutation (2 available); any Tacr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

impaired behavioral response to addictive substance ( J:171881 )

• amphetamine- or morphine-treated mice lack conditioned place preference unlike wild-type mice

impaired behavioral response to morphine ( J:171881 )

• morphine-treated mice lack conditioned place preference unlike wild-type mice

impaired conditioned place preference behavior ( J:171881 )

• amphetamine- or morphine-treated mice lack conditioned place preference unlike wild-type mice

impaired coordination ( J:171881 )

• on a rotarod

hyperactivity ( J:171881 )

• mice exhibit hyperactivity compared with wild-type mice

• however, hyperactivity is rescued by D-amphetamine or methylphenidate treatment

abnormal pain threshold ( J:127006 )

• F2rl1(PAR2)-agonist-induced hyperalgesia is not observed in mutants as is seen in wild-type mice

homeostasis/metabolism

abnormal dopamine level ( J:171881 )

• mice exhibit reduced basal dopamine efflux in the frontal cortex compared with wild-type mice

• amphetamine-treated mice lack a dopamine response compared with wild-type mice

abnormal noradrenaline level ( J:171881 )

• after a second potassium ion challenge, extracellular noradrenaline level is increased unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
attention deficit hyperactivity disorder		DOID:1094	OMIM:143465 OMIM:608903 OMIM:608904 OMIM:608905 OMIM:608906 OMIM:612311 OMIM:612312	J:171881

Allelic Composition	Tacr1^tm1Sph/Tacr1^tm1Sph
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1^tm1Sph mutation (2 available); any Tacr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased aggression ( J:46629 )

abnormal touch/ nociception ( J:46629 )

abnormal chemical nociception ( J:46629 )

• response to noxious stimuli not corollated to intensity of stimuli

• behavioral response to nociceptive thresholds unaffected

abnormal pain threshold ( J:46629 )

• stress induced analgesia reduced

hyperalgesia ( J:103700 )

• less increase in sensitivity to pain after M. tuberculosis infection than in controls

nervous system

decreased nerve fiber response intensity ( J:46629 )

• repetitive stimulation of unmyelinated fibers failed to increase response to subsequent stimulations

immune system

decreased inflammatory response ( J:46629 )

• inflammatory response to some noxious substances reduced

joint inflammation ( J:103700 )

• reduced synovial hyperplasia and inflammatory infiltrates

skeleton

joint inflammation ( J:103700 )

• reduced synovial hyperplasia and inflammatory infiltrates

respiratory system

abnormal respiratory mucosa goblet cell morphology ( J:105592 )

• less goblet cell hyperplasia in lungs after exposure to ovalbumin

abnormal pulmonary respiratory rate response ( J:89428 )

• respiratory frequency fails to increase in adult mice in response to hypoxia

increased airway responsiveness ( J:105592 )

• increased bronchoconstriction in response to carbachol

Allelic Composition	Tacr1^tm1Sph/Tacr1^tm1Sph
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * MF1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tacr1^tm1Sph mutation (2 available); any Tacr1 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

increased locomotor activity ( J:102131 )

• increased locomotor activity in light/dark box tests

abnormal thermosensation ( J:106631 )

• fail to develop morphine induced hypersensitivity to heat

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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