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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dldtm1Ptl
targeted mutation 1, Mulchand S Patel
MGI:2182403
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dldtm1Ptl/Dldtm1Ptl involves: 129P2/OlaHsd * Black Swiss MGI:3055026


Genotype
MGI:3055026
hm1
Allelic
Composition
Dldtm1Ptl/Dldtm1Ptl
Genetic
Background
involves: 129P2/OlaHsd * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dldtm1Ptl mutation (1 available); any Dld mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygous null embryos exhibit peri-gastrulation lethality and are resorbed by 9.5 dpc

embryo
• homozygous null embryos display a developmental cessation at the onset of gastrulation
• no mutant embryos develop normally to 8.5 dpc
• homozygous null embryos display a developmental delay at 7.5 dpc
• at 7.5 dpc, mutant embryos resemble 6.5-dpc wild-type egg cylinders in size and proportion
• at 7.5 dpc, mutant embryos are noticeably smaller than wild-type embryos
• at 7.5 dpc, the mutant visceral endoderm appears to proliferate relatively longer and forms a thickened columnar layer instead of the unicellular flat squamous layer found in wild-type

growth/size/body
• homozygous null embryos display a developmental delay at 7.5 dpc
• at 7.5 dpc, mutant embryos resemble 6.5-dpc wild-type egg cylinders in size and proportion
• at 7.5 dpc, mutant embryos are noticeably smaller than wild-type embryos





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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory