mortality/aging
• homozygous null embryos exhibit peri-gastrulation lethality and are resorbed by 9.5 dpc
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embryo
• homozygous null embryos display a developmental cessation at the onset of gastrulation
• no mutant embryos develop normally to 8.5 dpc
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• homozygous null embryos display a developmental delay at 7.5 dpc
• at 7.5 dpc, mutant embryos resemble 6.5-dpc wild-type egg cylinders in size and proportion
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• at 7.5 dpc, mutant embryos are noticeably smaller than wild-type embryos
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• at 7.5 dpc, the mutant visceral endoderm appears to proliferate relatively longer and forms a thickened columnar layer instead of the unicellular flat squamous layer found in wild-type
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growth/size/body
• homozygous null embryos display a developmental delay at 7.5 dpc
• at 7.5 dpc, mutant embryos resemble 6.5-dpc wild-type egg cylinders in size and proportion
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• at 7.5 dpc, mutant embryos are noticeably smaller than wild-type embryos
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