Phenotypes associated with this allele

• Allele Symbol: Dio2^tm1Vag
• Allele Name: targeted mutation 1, Valerie Anne Galton
• Allele ID: MGI:2182450
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dio2^tm1Vag/Dio2^tm1Vag	involves: 129S7/SvEvBrd * C57BL/6	MGI:3613455

Genotype
MGI:3613455

hm1

• Allelic Composition: Dio2^tm1Vag/Dio2^tm1Vag
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

impaired adaptive thermogenesis ( J:77694 )

• when exposed to cold, mice exhibit reduced body temperature and body weight compared with wild-type mice

increased thyroxine level ( J:77694 )

• with normal T3 levels

increased circulating thyroxine level ( J:72958 )

• 40% increase in serum T4 levels, however T3 levels are normal

• plasma T4 levels are also elevated in hypothyroid homozygotes implanted with a constant release T4 pellet, suggesting that clearance of T4 from plasma is reduced

abnormal thyroid-stimulating hormone level ( J:72958 )

• serum TSH levels in hypothyroid mice are suppressed only by T3 and not T4, unlike in wild-type in which both T3 and T4 suppress TSH levels

increased circulating thyroid-stimulating hormone level ( J:72958 )

• 100% increase in serum TSH levels

abnormal urine homeostasis ( J:104508 )

• urinary excretion of [¹²⁵I] iodide is reduced after injection of radiolabeled T4 (30% vs. 40% in controls)

growth/size/body

decreased body weight ( J:72958 )

• do not observe weight differences in males at 3 weeks of age, however at 4-7 weeks of age, males have a 9% decrease in body weight that is no longer seen at 8 weeks of age

postnatal growth retardation ( J:72958 )

• mild growth retardation in males at 4-7 weeks of age

digestive/alimentary system

abnormal feces composition ( J:104508 )

• fecal excretion of [¹²⁵I] iodothyronines is increased after injection of radiolabeled T4 (50% vs. 42% in controls)

renal/urinary system

abnormal urine homeostasis ( J:104508 )

• urinary excretion of [¹²⁵I] iodide is reduced after injection of radiolabeled T4 (30% vs. 40% in controls)