growth/size/body
N |
• mice exhibit normal size and weight
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Allele Symbol Allele Name Allele ID |
Dnmt1tm1Pwl targeted mutation 1, Peter W Laird MGI:2182453 |
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Summary |
5 genotypes
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• mice exhibit normal size and weight
|
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|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit reduced survival compared with wild-type mice
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• 61% of mice develop intestinal tumors
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• 61% of mice develop intestinal tumors
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• 29% of mice develop lymphomas
• mice develop lymphomas at an earlier age than in Mlh1tm1Lisk homozygotes
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• 61% of mice develop intestinal tumors
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• 61% of mice develop intestinal tumors
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit poorer survival than in Mlh1tm1Lisk homozygotes
|
• 90% of mice develop lymphomas
• mice develop lymphomas at an earlier age than in Mlh1tm1Lisk homozygotes
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|
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♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
• mice exhibit fewer intestinal polyps compared with ApcMin heterozygotes
• polyps are smaller than in ApcMin heterozygotes
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|
|
♀ | phenotype observed in females |
♂ | phenotype observed in males |
N | normal phenotype |
N |
• no intestinal polyps are observed unlike in ApcMin heterozygotes
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 08/02/2024 MGI 6.24 |
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