Analysis Tools|
Allele Symbol Allele Name Allele ID |
Dlg4tm1Grnt targeted mutation 1, Seth G N Grant MGI:2182460 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice show sebaceous glands with irregular surfaces
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• mice show sebaceous glands with irregular surfaces
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced numbers of homozygotes relative to expected when tested after birth
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• 42% are initially runted but attain normal size by 6 weeks of age
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• density of dendritic spines significantly reduced (by about 20%)
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• density of dendritic spines of the apical dendrites of CA1 pyramidal neurons is about 40% higher between 60 and 80 micrometers from the cell body
• neuron morphology is otherwise normal
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• 150 plulse trains of 5 Hz stimulations induced a more than twofold increase in long term potentiation than in wildtype
(J:98903)
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• at interpulse intervals of 20, 50,100, and 200 ms
in CA1 pyramidal cells
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• slower learning in a series of water maze tests
(J:77693)
• homozygotes learn little in the spatial water maze test regardless of the amount of training received
(J:98903)
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• fail to develop thermal hyperalgesia and mechanical allodynia after chronic constriction injury of the sciatic nerve
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• cold allodynia severely attenuated relative to controls after chronic constriction injury of the sciatic nerve
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• crosses of heterozygous Dlg3 and Dlg4 mice produce no double homozygotes; double mutants die perinatally with none surviving past day 3 postnatal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• crosses of heterozygous Dlg3 and Dlg4 mice produce a very low proportion of Dlg3tm1Grnt/+, Dlg4-null female mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 150 plulse trains of 5 Hz stimulations induced a more than twofold increase in long term potentiation (LTP) than in wildtype, which was similar to the LTP seen in single homozygous Dlgh4 mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no Dlg3tm1Grnt/y, Dlg4-null male mice mice are produced by crosses of heterozygous Dlg3 and Dlg4 mice; double mutants die perinatally
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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