Phenotypes associated with this allele

• Allele Symbol: Adra1d^tm1Gzt
• Allele Name: targeted mutation 1, Gozoh Tsujimoto
• Allele ID: MGI:2182469
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Adra1d^tm1Gzt/Adra1d^tm1Gzt	involves: 129 * C57BL/6J	MGI:2653869
hm2	Adra1d^tm1Gzt/Adra1d^tm1Gzt	involves: 129X1/SvJ * C57BL/6	MGI:3654757

Genotype
MGI:2653869

hm1

• Allelic Composition: Adra1d^tm1Gzt/Adra1d^tm1Gzt
• Genetic Background: involves: 129 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiovascular system physiology ( J:75628 )

• contractile response induced by norepinephrine or phenylephrine is reduced in aortic segments

decreased systemic arterial blood pressure ( J:75628 )

• pressor responses to phenylephrine and norepinephrine are decreased by 30-40%

• pressor response of isolated perfused mesenteric arterial beds to phenylephrine is significantly attenutated

decreased systemic arterial systolic blood pressure ( J:75628 )

• maintain significantly lower basal systolic blood pressure, however show no change in heart rate or cardiac function

hypotension ( J:75628 )

• modest hypotension under unanesthetized conditions

Genotype
MGI:3654757

hm2

• Allelic Composition: Adra1d^tm1Gzt/Adra1d^tm1Gzt
• Genetic Background: involves: 129X1/SvJ * C57BL/6

behavior/neurological

abnormal spatial working memory ( J:91151 )

• in the Y-maze task requiring working memory or attention, mice display impaired spontaneous alternation performance, however show normal spatial learning

decreased startle reflex ( J:91151 )

• tend to show lower levels of acoustic startle responses than wild-type at lower pulse intensities, however the acoustic prepulse inhibition is not impaired

enhanced coordination ( J:91151 )

• exhibit better motor coordination a the highest rotating speed of the rotarod, however locomotor activity and swimming ability in the water maze are normal

muscle

abnormal muscle tone ( J:91151 )

• exhibit stronger muscle tone in the traction meter test

nervous system

abnormal prepulse inhibition ( J:91151 )

• MK-801, an NMDA receptor antagonist, fails to produce acoustic prepulse inhibition deficits as in wild-type, however under basal conditions, acoustic prepulse inhibition is not impaired