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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Piwil1tm1Hfl
targeted mutation 1, Haifan Lin
MGI:2182488
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Piwil1tm1Hfl/Piwil1tm1Hfl involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:3040658


Genotype
MGI:3040658
hm1
Allelic
Composition		 Piwil1tm1Hfl/Piwil1tm1Hfl
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Piwil1tm1Hfl mutation (2 available); any Piwil1 mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male germ cell morphology ( J:77015 )
• degenerating germ cells with pycnotic nuclei and a dramatic increase in apoptotic cells are seen in testes from homozygotes
arrest of male meiosis ( J:77015 )
• no spermatids beyond step 4 of spermatogenesis are seen in homozygotes
decreased testis weight ( J:77015 )
• adult testes are 29% smaller by weight in mutants compared to controls
male infertility ( J:77015 )
• males are completely sterile

endocrine/exocrine glands
decreased testis weight ( J:77015 )
• adult testes are 29% smaller by weight in mutants compared to controls

cellular
abnormal male germ cell morphology ( J:77015 )
• degenerating germ cells with pycnotic nuclei and a dramatic increase in apoptotic cells are seen in testes from homozygotes
arrest of male meiosis ( J:77015 )
• no spermatids beyond step 4 of spermatogenesis are seen in homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
10/09/2024
MGI 6.24 		The Jackson Laboratory