Phenotypes associated with this allele

• Allele Symbol: Piwil1^tm1Hfl
• Allele Name: targeted mutation 1, Haifan Lin
• Allele ID: MGI:2182488
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Piwil1^tm1Hfl/Piwil1^tm1Hfl	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J	MGI:3040658

Genotype
MGI:3040658

hm1

• Allelic Composition: Piwil1^tm1Hfl/Piwil1^tm1Hfl
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal male germ cell morphology ( J:77015 )

♂ • degenerating germ cells with pycnotic nuclei and a dramatic increase in apoptotic cells are seen in testes from homozygotes

arrest of male meiosis ( J:77015 )

♂ • no spermatids beyond step 4 of spermatogenesis are seen in homozygotes

decreased testis weight ( J:77015 )

♂ • adult testes are 29% smaller by weight in mutants compared to controls

male infertility ( J:77015 )

♂ • males are completely sterile

endocrine/exocrine glands

decreased testis weight ( J:77015 )

♂ • adult testes are 29% smaller by weight in mutants compared to controls

cellular

abnormal male germ cell morphology ( J:77015 )

♂ • degenerating germ cells with pycnotic nuclei and a dramatic increase in apoptotic cells are seen in testes from homozygotes

arrest of male meiosis ( J:77015 )

♂ • no spermatids beyond step 4 of spermatogenesis are seen in homozygotes