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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gasttm1Lcs
targeted mutation 1, Linda C Samuelson
MGI:2182563
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Gasttm1Lcs/Gasttm1Lcs involves: 129S1/Sv * 129X1/SvJ * BALB/c MGI:4821147
hm2
 		Gasttm1Lcs/Gasttm1Lcs involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:2672026
ht3
 		Gasttm1Lcs/Gast+ involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3625151
cx4
 		Atp4btm1Ird/Atp4btm1Ird
Gasttm1Lcs/Gasttm1Lcs 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc MGI:3624965


Genotype
MGI:4821147
hm1
Allelic
Composition		 Gasttm1Lcs/Gasttm1Lcs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gasttm1Lcs mutation (1 available); any Gast mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating unsaturated transferrin level ( J:142455 )
• at 4 weeks, transferrin saturation is reduced 0.76-fold compared with wild-type mice
abnormal iron homeostasis ( J:142455 )
• iron absorption in juvenile mice is increased 6-fold compared to in wild-type mice
• however, iron absorption at 10 weeks is normal
decreased circulating iron level ( J:142455 )
• however, iron levels at 10 weeks are normal




Genotype
MGI:2672026
hm2
Allelic
Composition		 Gasttm1Lcs/Gasttm1Lcs
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gasttm1Lcs mutation (1 available); any Gast mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal stomach mucosa morphology ( J:97527 )
• expanded surface mucus layer in the fundus
abnormal gastric parietal cell morphology ( J:77780 , J:107860 )
• 23% reduction in parietal cells (J:77780)
• larger numbers of parietal cells recovered from mucosa relative to controls but size of cells reduced (J:107860)
• calcium levels in parietal cells significantly higher than in controls (J:107860)
increased stomach tumor incidence ( J:97527 )
• macroscopically visible tumors present in 60% of mice at 12 months of age
• tumors all in antral region
abnormal digestive system physiology ( J:97527 )
• increased levels of apoptosis in the fundus and significantly reduced apoptosis in the antrum
abnormal digestive secretion ( J:77780 , J:97527 )
• complete loss of gastric acid secretion (J:77780)
stomach inflammation ( J:97527 )
• increased inflammatory cell infiltration of the mucosa in the antrum
• increased levels of antral polymorphonuclear neutrophils and T cells

neoplasm
increased stomach tumor incidence ( J:97527 )
• macroscopically visible tumors present in 60% of mice at 12 months of age
• tumors all in antral region

immune system
stomach inflammation ( J:97527 )
• increased inflammatory cell infiltration of the mucosa in the antrum
• increased levels of antral polymorphonuclear neutrophils and T cells

endocrine/exocrine glands
abnormal gastric parietal cell morphology ( J:77780 , J:107860 )
• 23% reduction in parietal cells (J:77780)
• larger numbers of parietal cells recovered from mucosa relative to controls but size of cells reduced (J:107860)
• calcium levels in parietal cells significantly higher than in controls (J:107860)




Genotype
MGI:3625151
ht3
Allelic
Composition		 Gasttm1Lcs/Gast+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gasttm1Lcs mutation (1 available); any Gast mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal digestive secretion ( J:77780 )
• 2 fold reduction in gastrin in the stomach but plasma levels remain normal




Genotype
MGI:3624965
cx4
Allelic
Composition		 Atp4btm1Ird/Atp4btm1Ird
Gasttm1Lcs/Gasttm1Lcs
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * BALB/cCrSlc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp4btm1Ird mutation (2 available); any Atp4b mutation (31 available)
Gasttm1Lcs mutation (1 available); any Gast mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal stomach mucosa morphology ( J:108678 )
• hypertrophy of the gastric mucosa is eliminated in the double homozygote
abnormal gastric gland morphology ( J:108678 )
• moderate increase in apoptotic cells and in immature cell numbers
abnormal gastric chief cell morphology ( J:108678 )
• near total absence of zymogenic cells
abnormal gastric parietal cell morphology ( J:108678 )
• sightly decreased number of parietal cells about half of which are vacuolated and half are normal

endocrine/exocrine glands
abnormal gastric gland morphology ( J:108678 )
• moderate increase in apoptotic cells and in immature cell numbers
abnormal gastric chief cell morphology ( J:108678 )
• near total absence of zymogenic cells
abnormal gastric parietal cell morphology ( J:108678 )
• sightly decreased number of parietal cells about half of which are vacuolated and half are normal




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory