Phenotypes associated with this allele

• Allele Symbol: Cdh1^tm1Cbm
• Allele Name: targeted mutation 1, Carmen Birchmeier
• Allele ID: MGI:2182564
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cdh1^tm1Cbm/Cdh1^tm1Cbm	involves: 129P2/OlaHsd	MGI:3830620
cx2	Apc^tm1Rak/Apc^+ Cdh1^tm1Cbm/Cdh1^+	involves: 129P2/OlaHsd * C57BL/6J	MGI:3830619

Genotype
MGI:3830620

hm1

• Allelic Composition: Cdh1^tm1Cbm/Cdh1^tm1Cbm
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:22631 )

• no viable mice are produced

embryo

abnormal preimplantation embryo development ( J:22631 )

failure of blastocyst to hatch from the zona pellucida ( J:22631 )

• hatching from the zona pellucida is never observed

failure of morula compaction ( J:22631 )

• the adhesive cells of the morula dissociate shortly after compaction and appear morphologically nonpolar

• notably, blastomers are still able to form desmosomes and tight junctions at sites of distorted cell-cell contact

absent blastocoele ( J:22631 )

• morulas grown in culture become decompacted, depolarize morphologically and fail to form a blastocoel as do wild-type morulas

Genotype
MGI:3830619

cx2

• Allelic Composition: Apc^tm1Rak/Apc⁺; Cdh1^tm1Cbm/Cdh1⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

neoplasm

increased intestinal adenocarcinoma incidence ( J:65142 )

• mice develop an average of 11.3 tumors per animal in the small intestine unlike wild-type mice

• mice develop more tumors than in Apc^tm1Rak heterozygotes with tumor size the same as in Apc^tm1Rak heterozygotes

• tumors are invasive although no metastasis is detected

increased stomach tumor incidence ( J:65142 )

• 5-fold more mice develop gastric cancer compared to in Apc^tm1Rak heterozygotes

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:65142 )

• mice develop an average of 11.3 tumors per animal in the small intestine unlike wild-type mice

• mice develop more tumors than in Apc^tm1Rak heterozygotes with tumor size the same as in Apc^tm1Rak heterozygotes

• tumors are invasive although no metastasis is detected

increased stomach tumor incidence ( J:65142 )

• 5-fold more mice develop gastric cancer compared to in Apc^tm1Rak heterozygotes