Phenotypes associated with this allele

• Allele Symbol: Gast^tm1Tcw
• Allele Name: targeted mutation 1, Timothy C Wang
• Allele ID: MGI:2182565
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gast^tm1Tcw/Gast^tm1Tcw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:2672025

Genotype
MGI:2672025

hm1

• Allelic Composition: Gast^tm1Tcw/Gast^tm1Tcw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal colon morphology ( J:43358 )

• decrease in proliferation of the colonic mucosa compared to wild-type

abnormal stomach mucosa morphology ( J:43358 )

• decrease in number of enterochromaffin-like cells cells

• atrophy of the oxyntic mucosa, resulting in decreased thickness, particularly in the basal and pit regions

abnormal gastric chief cell morphology ( J:43358 )

• decrease in number of chief cells

abnormal gastric parietal cell morphology ( J:43358 )

• 35% decrease in number of parietal cells

abnormal mucous neck cell morphology ( J:43358 )

• increase in the number of mucous neck cells with an expansion into the basal region of the fundic glands

increased stomach pH ( J:43358 )

• basal gastric pH in fasted mutants is higher than in controls, indicating a decrease in gastric acid production

endocrine/exocrine glands

abnormal gastric chief cell morphology ( J:43358 )

• decrease in number of chief cells

abnormal gastric parietal cell morphology ( J:43358 )

• 35% decrease in number of parietal cells

abnormal mucous neck cell morphology ( J:43358 )

• increase in the number of mucous neck cells with an expansion into the basal region of the fundic glands