Analysis Tools|
Allele Symbol Allele Name Allele ID |
Eif2ak2tm1Cwe targeted mutation 1, Charles Weissmann MGI:2182566 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• dendritic cells in mutants show relatively normal induction of T cell stimulatory molecules and cytokine mRNAs when stimulated with poly(I:C) or LPS
• dendritic cells show essentially normal responses and maturation upon infection with NDV
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• proliferative responses of both CD4+ and CD8+ T-cells from sensitized mice is somewhat increased
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• proliferative responses of both CD4+ and CD8+ T-cells from sensitized mice is somewhat increased
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• exaggerated response to challenge after presensitization in contact hypersensitivity test
• effect can be transferred to naive mice using CD8+ cells from sensitized mice
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• a 2 fold increase in Il4 production by CD44+ cells
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• susceptibility to encephalomyocarditis virus tested
• response to infection and survival were similar to control mice; however, pretreatment of mice with IFNgamma failed to improve survival as it did in controls
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• proliferative responses of both CD4+ and CD8+ T-cells from sensitized mice is somewhat increased
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• susceptibility to encephalomyocarditis virus tested
• antiviral effect of interferon was suppressed even more than in the case of either single homozygote
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viability is increased up to 63% for mutant mice homozygous for the mutation in Eif2ak2 compared to mutant mice wild-type for Eif2ak2 (~32% viability)
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• increase in the junctional zone
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• spongiotrophoblasts have more diploid DNA content at E14.5
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• increased diploid DNA content at E14.5
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• ossification in the jawbone is improved compared to mutant mice wild-type for Eif2ak2
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• spongiotrophoblasts and glycogen cells have more diploid DNA content at E14.5
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• elevated gammaH2A.X signalling indicating decreased DNA repair and persistence of DNA damage in spongiotrophoblasts
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• elevated gammaH2A.X signalling indicating decreased DNA repair and persistence of DNA damage in spongiotrophoblasts
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• viability is increased up to 57% for mutant mice homozygous for the mutation in Eif2ak2 compared to mutant mice wild-type for Eif2ak2 (~30% viability)
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• increase in forelimb length compared to mutant mice wild-type for Eif2ak2
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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