All Phenotypes Eif2ak2<tm1Cwe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eif2ak2^tm1Cwe
targeted mutation 1, Charles Weissmann
MGI:2182566

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe	involves: 129	MGI:3698179
hm2	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe	involves: 129S/SvEv * C57BL/6	MGI:3039220
cx3	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe Rnasel^tm1Slvm/Rnasel^tm1Slvm	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6	MGI:3039029
cx4	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe Nipbl^{Gt(RRS564)Byg}/Nipbl⁺	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1	MGI:7491947
cx5	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe Hdac8^tm1.2Eno/Y	involves: 129/Sv * 129S6/SvEvTac * C57BL/6J	MGI:7491953

Allelic Composition	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe
Genetic Background	involves: 129

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak2^tm1Cwe mutation (2 available); any Eif2ak2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:114555 )

N	• dendritic cells in mutants show relatively normal induction of T cell stimulatory molecules and cytokine mRNAs when stimulated with poly(I:C) or LPS • dendritic cells show essentially normal responses and maturation upon infection with NDV

Allelic Composition	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak2^tm1Cwe mutation (2 available); any Eif2ak2 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

increased T cell proliferation ( J:66112 )

• proliferative responses of both CD4+ and CD8+ T-cells from sensitized mice is somewhat increased

immune system

increased T cell proliferation ( J:66112 )

• proliferative responses of both CD4+ and CD8+ T-cells from sensitized mice is somewhat increased

increased susceptibility to type IV hypersensitivity reaction ( J:66112 )

• exaggerated response to challenge after presensitization in contact hypersensitivity test

• effect can be transferred to naive mice using CD8+ cells from sensitized mice

increased interleukin-4 secretion ( J:66112 )

• a 2 fold increase in Il4 production by CD44+ cells

increased susceptibility to Picornaviridae infection ( J:30617 )

• susceptibility to encephalomyocarditis virus tested

• response to infection and survival were similar to control mice; however, pretreatment of mice with IFNgamma failed to improve survival as it did in controls

hematopoietic system

increased T cell proliferation ( J:66112 )

• proliferative responses of both CD4+ and CD8+ T-cells from sensitized mice is somewhat increased

Allelic Composition	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe Rnasel^tm1Slvm/Rnasel^tm1Slvm
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak2^tm1Cwe mutation (2 available); any Eif2ak2 mutation (37 available)
Rnasel^tm1Slvm mutation (0 available); any Rnasel mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to Picornaviridae infection ( J:55974 )

• susceptibility to encephalomyocarditis virus tested

• antiviral effect of interferon was suppressed even more than in the case of either single homozygote

Allelic Composition	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe Nipbl^{Gt(RRS564)Byg}/Nipbl⁺
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6J * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak2^tm1Cwe mutation (2 available); any Eif2ak2 mutation (37 available)
Nipbl^{Gt(RRS564)Byg} mutation (0 available); any Nipbl mutation (124 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:297059 )

• viability is increased up to 63% for mutant mice homozygous for the mutation in Eif2ak2 compared to mutant mice wild-type for Eif2ak2 (~32% viability)

embryo

abnormal placenta junctional zone morphology ( J:297059 )

• increase in the junctional zone

abnormal spongiotrophoblast cell morphology ( J:297059 )

• spongiotrophoblasts have more diploid DNA content at E14.5

abnormal trophoblast glycogen cell morphology ( J:297059 )

• increased diploid DNA content at E14.5

skeleton

abnormal bone ossification ( J:297059 )

• ossification in the jawbone is improved compared to mutant mice wild-type for Eif2ak2

cellular

abnormal chromosome number ( J:297059 )

• spongiotrophoblasts and glycogen cells have more diploid DNA content at E14.5

abnormal DNA repair ( J:297059 )

• elevated gammaH2A.X signalling indicating decreased DNA repair and persistence of DNA damage in spongiotrophoblasts

homeostasis/metabolism

abnormal DNA repair ( J:297059 )

• elevated gammaH2A.X signalling indicating decreased DNA repair and persistence of DNA damage in spongiotrophoblasts

Allelic Composition	Eif2ak2^tm1Cwe/Eif2ak2^tm1Cwe Hdac8^tm1.2Eno/Y
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2ak2^tm1Cwe mutation (2 available); any Eif2ak2 mutation (37 available)
Hdac8^tm1.2Eno mutation (0 available); any Hdac8 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:297059 )

• viability is increased up to 57% for mutant mice homozygous for the mutation in Eif2ak2 compared to mutant mice wild-type for Eif2ak2 (~30% viability)

limbs/digits/tail

abnormal limb morphology ( J:297059 )

• increase in forelimb length compared to mutant mice wild-type for Eif2ak2

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