Analysis Tools
mortality/aging
|
• most null mice with craniofacial malformations die shortly after birth
• mice with less severe craniofacial defects survive longer
|
growth/size/body
cleft palate
(
J:77779
)
|
• null mice sometimes exhibit cleft nose and palate
|
 |
• in females, absolute body weight is 20% lower than in wild-type females at P23
• however, no differences in body weight are observed at P60 or P120
|
embryo
|
• cells from the edges of the cranial neural folds showed a significant decrease in adhesion to Epha7 coated dishes compared to wild-type cells
|
|
• 17% of null mice display neural tube defects caused by the failure of the neural folds to fuse in the dorsal midline
|
|
• failure to close the cranial neural tube
• although the neural folds become juxtaposed in the dorsal midline, they fail to fuse in some embryos and continued cell proliferation leads to eversion of the neural folds
|
craniofacial
cleft palate
(
J:77779
)
|
• null mice sometimes exhibit cleft nose and palate
|
nervous system
|
• 17% of null mice display neural tube defects caused by the failure of the neural folds to fuse in the dorsal midline
|
|
• failure to close the cranial neural tube
• although the neural folds become juxtaposed in the dorsal midline, they fail to fuse in some embryos and continued cell proliferation leads to eversion of the neural folds
|
|
• most null mice with craniofacial malformations lack a brain
|
|
• although arborization of nasal axons is normal, more anterior arborization is also seen
|
anencephaly
(
J:77779
)
|
• some null mice display anencephaly
|
reproductive system
|
N |
• ovary to body weight ratio is normal at P23, P60, and P120
|
|
|
• after treatment with eCG followed by hCG, ovaries show a 1.5-fold increase in the number of oocytes aberrantly retained in the corpora lutea
• however, the total number of corpora lutea per mouse is normal
|
|
|
• after treatment with eCG followed by hCG, ovaries show a 2.6-fold increase in the number of follicles that have undergone cumulus expansion
|
|
|
• adult ovaries show a 4-fold increase in multioocyte follicles (MOFs)
• however, no difference in MOF number is detected at 3 weeks of age, suggesting follicle merging
|
|
|
• after gonadotropin stimulation, ovaries exhibit granulosa cell and follicular fluid emboli and fibrin thrombi in blood vessels
|
|
|
• after gonadotropin stimulation, ovaries exhibit interstitial hemorrhage near the site of nonapical follicle rupture
|
|
|
• after gonadotropin stimulation, ovarian mRNA levels of several luteinizing hormone (LH)-responsive genes are reduced, suggesting a partially attenuated response to LH
• after gonadotropin stimulation, ovaries exhibit nonapical follicle rupture resulting in interstitial and intraluminal cumulus oocyte complex (COC) release, as well as a 50% increase in the number of oocytes trapped within luteinized follicles
• however, no differences in serum estradiol and progesterone levels are observed in response to gonadotropin stimulation and both Lhcgr and Fshr mRNA levels are normal
|
|
|
• after treatment of P23-P25 females with equine chorionic gonadotropin (eCG) followed by human CG (hCG), average oocyte yield is 38% lower than for wild-type females
|
|
|
• adult females are subfertile
|
|
|
• in a continuous breeding study, females produced 40% smaller litters than wild-type females
• however, average number of days between litters is normal
|
cardiovascular system
|
|
• after gonadotropin stimulation, ovaries exhibit interstitial hemorrhage near the site of nonapical follicle rupture
|
endocrine/exocrine glands
|
|
• after treatment with eCG followed by hCG, ovaries show a 1.5-fold increase in the number of oocytes aberrantly retained in the corpora lutea
• however, the total number of corpora lutea per mouse is normal
|
|
|
• after treatment with eCG followed by hCG, ovaries show a 2.6-fold increase in the number of follicles that have undergone cumulus expansion
|
|
|
• adult ovaries show a 4-fold increase in multioocyte follicles (MOFs)
• however, no difference in MOF number is detected at 3 weeks of age, suggesting follicle merging
|
|
|
• after gonadotropin stimulation, ovaries exhibit granulosa cell and follicular fluid emboli and fibrin thrombi in blood vessels
|
|
|
• after gonadotropin stimulation, ovaries exhibit interstitial hemorrhage near the site of nonapical follicle rupture
|
digestive/alimentary system
cleft palate
(
J:77779
)
|
• null mice sometimes exhibit cleft nose and palate
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| anencephaly | DOID:0060668 |
OMIM:206500 |
J:77779 | |
