mortality/aging
• by E6.5; followed by reduction in adherens junctions and morphological signs of cellular degeneration
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embryo
• defects in cell-cell adhesion results in partial delamination of the endodermal layer; disruptions are also seen in the ectodermal layer
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• defects in cell-cell adhesion results in partial delamination of the endodermal layer; disruptions are also seen in the ectodermal layer
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• mutant embryos are smaller than littermates
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• absence of desmosome
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• defects in egg cylinder elongation
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growth/size/body
• mutant embryos are smaller than littermates
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