Phenotypes associated with this allele

• Allele Symbol: Fes^tm2Mcs
• Allele Name: targeted mutation 2, M Celeste Simon
• Allele ID: MGI:2182589
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fes^tm2Mcs/Fes^tm2Mcs	chimera involves: 129X1/SvJ * C57BL/6	MGI:3844852
ht2	Fes^tm2Mcs/Fes^+	chimera involves: 129X1/SvJ * C57BL/6	MGI:3844853

Genotype
MGI:3844852

hm1

• Allelic Composition: Fes^tm2Mcs/Fes^tm2Mcs
• Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:76509 )

• embryos 75% chimeric for homozygous mutant cells are identifiable at E13.5

• only embryos 25% chimeric or less for homozygous mutant cells are identifiable at E16.5

cardiovascular system

abnormal vasculogenesis ( J:76509 )

• blood vessels in mutant embryos chimeric for homozygous mutant cells are often unorganized and disrupted

Genotype
MGI:3844853

ht2

• Allelic Composition: Fes^tm2Mcs/Fes⁺
• Genetic Background: chimera involves: 129X1/SvJ * C57BL/6

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:76509 )

• no mice chimeric for heterozygous cells are born

• highly chimeric mice die between E14.5 and E17.5

• 85-100% of highly chimeric mice are dead by E15.5-E16.5

growth/size/body

enlarged heart ( J:76509 )

down-turned corners of mouth ( J:76509 )

• downward angle

downturned snout ( J:76509 )

• downward angle

increased fetal weight ( J:76509 )

• chimeric mice are enlarged in size by E15.5-E16.5

• weight is directly related to the degree of chimerism

distended abdomen ( J:76509 )

homeostasis/metabolism

hydrops fetalis ( J:76509 )

• embryos swollen

cardiovascular system

abnormal heart morphology ( J:76509 )

abnormal myocardial trabeculae morphology ( J:76509 )

• trabeculation increases with increasing level of chimerism

thin myocardium compact layer ( J:76509 )

ventricular septal defect ( J:76509 )

enlarged heart ( J:76509 )

dilated heart ventricle ( J:76509 )

hemorrhage ( J:76509 )

• severe systemic hemorrhage

• punctate lesions

gastrointestinal hemorrhage ( J:76509 )

• pools of blood in the abdominal cavity

liver hemorrhage ( J:76509 )

• hemorrhagic liver in 77% of embryos

nervous system

enlarged lateral ventricles ( J:76509 )

abnormal frontal lobe morphology ( J:76509 )

• enlarged and displaced in a cephalic direction

craniofacial

down-turned corners of mouth ( J:76509 )

• downward angle

downturned snout ( J:76509 )

• downward angle

digestive/alimentary system

gastrointestinal hemorrhage ( J:76509 )

• pools of blood in the abdominal cavity

muscle

abnormal myocardial trabeculae morphology ( J:76509 )

• trabeculation increases with increasing level of chimerism

thin myocardium compact layer ( J:76509 )

liver/biliary system

liver hemorrhage ( J:76509 )

• hemorrhagic liver in 77% of embryos