Phenotypes associated with this allele

• Allele Symbol: Eif2ak2^tm1Jcbe
• Allele Name: targeted mutation 1, John C Bell
• Allele ID: MGI:2182590
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe	involves: 129S4/SvJae	MGI:3852125
hm2	Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe	involves: 129S4/SvJae * BALB/c	MGI:3852121
cx3	Adar^em1Stsn/Adar^tm1Olds Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe	involves: 129S/SvEv * 129S4/SvJae * C57BL/6J	MGI:7281849

Genotype
MGI:3852125

hm1

• Allelic Composition: Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:63671 )

• infection of mice with VSV or mouse-adapted influenza induces greater lethality than in similarly treated wild-type mice

immune system

immune system phenotype ( J:63671 )

N • mice exhibit normal immune systems in the absence of viral infection

increased susceptibility to Riboviria infection ( J:63671 , J:167126 )

• mouse embryonic fibroblasts infected with vesicular stomatitis virus (VSV) exhibit increased apoptosis and viral replication compared to similarly treated wild-type cells (J:63671)

• infection of mice with VSV induces respiratory distress, paralytic disease, and premature lethality unlike in wild-type mice (J:63671)

• however, pre-treatment with IFNalpha/beta or gamma restores protection against virally induced apoptosis (J:63671)

• mouse embryonic fibroblasts exhibit increased susceptibility to RNA virus replication compared with wild-type cells (J:167126)

increased susceptibility to Orthomyxoviridae infection ( J:63671 )

• mice infected with mouse-adapted influenza exhibit increased apoptosis in the lungs and lethality compared with similarly treated wild-type mice

• replication of mouse-adapted influenza in mouse embryonic fibroblasts is increased compared to in similarly treated wild-type mice

cellular

decreased sensitivity to induced cell death ( J:63671 )

• mouse embryonic fibroblasts are resistant to double-strand RNA-induced apoptosis unlike wild-type cells

increased sensitivity to induced cell death ( J:63671 )

• mouse embryonic fibroblasts infected with vesicular stomatitis virus exhibit increased apoptosis compared to similarly treated wild-type cells

• however, pre-treatment with IFNalpha/beta or gamma restores protection against virally induced apoptosis

Genotype
MGI:3852121

hm2

• Allelic Composition: Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe
• Genetic Background: involves: 129S4/SvJae * BALB/c

hematopoietic system

decreased erythroid progenitor cell number ( J:53258 )

• fewer colonies form from bone marrow cells in response to erythropoietin compared to in similarly treated wild-type cells

neoplasm

neoplasm ( J:53258 )

N • mice do not exhibit altered tumorigenesis

cellular

cellular phenotype ( J:53258 )

N • mouse embryonic fibroblasts exhibit normal stress-induced apoptosis

immune system

immune system phenotype ( J:53258 )

N • mice exhibit normal susceptibility and response to viral infection

Genotype
MGI:7281849

cx3

• Allelic Composition: Adar^em1Stsn/Adar^tm1Olds; Eif2ak2^tm1Jcbe/Eif2ak2^tm1Jcbe
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6J

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:308678 )

• normal expression of interferon-stimulated genes in kidney

• normal expression of integrated stress response (ISR) in cerebellum, kidney and liver

abnormal homeostasis ( J:308678 )

• increased expression of interferon-stimulated genes in cerebellum and liver

• normal expression of interferon-stimulated genes in kidney

growth/size/body

growth/size/body region phenotype ( J:308678 )

• normal weight, weight gain and growth

mortality/aging

mortality/aging ( J:308678 )

• normal survival