Analysis Tools|
Allele Symbol Allele Name Allele ID |
Ungtm1Tld targeted mutation 1, Tomas Lindahl MGI:2182610 |
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| Summary |
8 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• no overt phenotype up to one year; fertile and developed normally
• tumor free until 12 - 18 months
• detailed histopathology of male and female mice at 1 year showed no gross abnormalities
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mouse embryonic fibroblasts exhibit increased susceptibility to 5-hydroxymethyluridine and 5-fluorouracil toxicity compared with wild-type cells
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• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells
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• reduced IgG1 class switch recombination
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• mice exhibit a marginal increase in germinal center B cell mutation frequency compared with wild-type mice
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• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells
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• reduced IgG1 class switch recombination
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• mice exhibit a marginal increase in germinal center B cell mutation frequency compared with wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased mortality after 18 months of age, with decreased median life span compared to controls
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• palpable in spleen and mesenteric lymph nodes of 12% of the mice after 18 months of age
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• apparent after 18 months of age
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• apparent after 18 months of age
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• apparent after 18 months of age
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• altered isotype balance; class switching after LPS stimulation was diminished, but not as a result of lack of B cell proliferation
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• only IgG3 decreased
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• altered isotype balance
• class switching after LPS stimulation was diminished, but not as a result of lack of B cell prolferation
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• apparent after 18 months of age
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• apparent after 18 months of age
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• apparent after 18 months of age
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• altered isotype balance; class switching after LPS stimulation was diminished, but not as a result of lack of B cell proliferation
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• only IgG3 decreased
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• altered isotype balance
• class switching after LPS stimulation was diminished, but not as a result of lack of B cell prolferation
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• apparent after 18 months of age
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• apparent after 18 months of age
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• apparent after 18 months of age
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• apparent after 18 months of age
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• apparent after 18 months of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Pcnatm1Jcbs homozygotes
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• mice exhibit a reduction in total mutation frequency in germinal center B cell compared with wild-type mice that is similar to that observed in Pcnatm1Jcbs homozygotes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal life expectancy
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• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells
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• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch
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• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells
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• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mean life expectancy is 107 days compared with 223 days for Msh2tm1Htr homozygotes
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• fewer than expected mice are identified at weaning
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• in all mice that die
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• in 4 of 5 mice with tumors
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal life expectancy
|
|
• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells
|
|
• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch
|
|
• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells
|
|
• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch
|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mean life expectancy is 107 days compared with 223 days for Msh2tm1Htr homozygotes
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• fewer than expected mice are identified at weaning
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• in all mice that die
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• in 4 of 5 mice with tumors
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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