behavior/neurological
• male null animals show an age-dependent impaired spatial memory retention compared to age-matched controls
(J:105032)
• females show impairments in spatial learning and memory in the water-maze test compared to age-matched controls
(J:106034)
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• female null animals show enhanced emotional memory retention in passive avoidance training compared to wild-type
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• male null mice spend less time exploring than control mice; 3-5 month old null mice show reduced levels of novel object recognition than aged-matched controls or older null animals and age-matched controls
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• young male null mice show enhanced spatial learning in water-maze tests compared to age-matched controls
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• 3-5 month old male null mice show more anxiety-like behavior and move less than age-matched wild-type mice assessed by time spent in the center in an open field test; 12-14 month old mice null mice show increased anxiety-like responses also, but these are somewhat lower than the response of young null animals
(J:105032)
• in a light-dark test, male null mice move less and show more anxiety-like behavior than wild-type (as measured by increased time spent in the dark); older mice show reduced anxiety-like behavior than young ones
(J:105032)
• 3-5 month old female null mice show more anxiety-like behavior and move less than age-matched wild-type mice assessed by time spent in the center in an open field test; 12-14 month old mice null mice show similar increased anxiety-like responses
(J:106034)
• in a light-dark test, young and older female null mice move less and show more anxiety-like behavior than wild-type (as measured by increased time spent in the dark)
(J:106034)
• in an elevated plus-maze, older null females move less and show less total maze-arm entries than age matched controls
(J:106034)
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