Analysis Tools
reproductive system
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• some mice exhibit hemorrhagic large follicles with a trapped oocyte
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• 44% of eggs produced by female mice are abnormal with eggs that are fragmented, without polar bodies, or unfertilized
• 70% of eggs produced by superovulated female mice are abnormal
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• females produce fewer oocytes
• however, all superovulated females produce normal numbers of oocytes
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• synaptonemal complexes of pachytene spermatocytes are malformed
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• in some mice
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• some mice exhibit hemorrhagic large follicles with a trapped oocyte
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• some mice exhibit hemorrhagic large follicles with a trapped oocyte
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small testis
(
J:76942
)
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• seminiferous tubules lack meiotic spermatocytes and post-meiotic spermatids
• epididymis contain fewer sperm than in wild-type mice
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• spermatocytes undergo apoptosis during late pachytene of meiotic prophase and during meiotic divisions
• synaptonemal complexes of pachytene spermatocytes are malformed
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• female mice are hypofertile with some failing to produce offspring and others producing smaller than normal litters
• however, all superovulated females produce oocytes
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• female mice are hypofertile with some failing to produce offspring and others producing smaller than normal litters
• offspring of homozygous females exhibit increased embryonic lethality at E9.5 compared to offspring of heterozygous mice
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nervous system
cardiovascular system
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• some mice exhibit hemorrhagic large follicles with a trapped oocyte
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endocrine/exocrine glands
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• some mice exhibit hemorrhagic large follicles with a trapped oocyte
|
|
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• in some mice
|
|
|
• some mice exhibit hemorrhagic large follicles with a trapped oocyte
|
|
|
• some mice exhibit hemorrhagic large follicles with a trapped oocyte
|
small testis
(
J:76942
)
|
|
|
cellular
|
|
• 44% of eggs produced by female mice are abnormal with eggs that are fragmented, without polar bodies, or unfertilized
• 70% of eggs produced by superovulated female mice are abnormal
|
|
|
• females produce fewer oocytes
• however, all superovulated females produce normal numbers of oocytes
|
|
|
• seminiferous tubules lack meiotic spermatocytes and post-meiotic spermatids
• epididymis contain fewer sperm than in wild-type mice
|
|
|
• spermatocytes undergo apoptosis during late pachytene of meiotic prophase and during meiotic divisions
• synaptonemal complexes of pachytene spermatocytes are malformed
|
|
• synaptonemal complexes of pachytene spermatocytes are malformed
|
|
• offspring of homozygous females exhibit increased embryonic lethality at E9.5 compared to offspring of heterozygous mice
|
growth/size/body
|
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• some mice exhibit hemorrhagic large follicles with a trapped oocyte
|
