nervous system
• at ages E11.5 and E12.5, neurons expressing GABAergic markers are reduced in dorsal spinal cord; number of neurons expressing Gad1 is lower than in wild-type mice in lumbar spinal cord at E12.5
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• at E12.5, a marked increase in dorsal glutaminergic neurons (VGLUT2-positive) neurons is seen in the caudal spinal cord relative to controls; this increase corresponds to decrease in GABAergic neurons, suggesting switch of neurotransmitter fate
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muscle
N |
• perineal muscles form normally
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• all distal limb muscles are absent
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