Phenotypes associated with this allele

• Allele Symbol: Drgx^tm1And
• Allele Name: targeted mutation 1, David J Anderson
• Allele ID: MGI:2182636
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Drgx^tm1And/Drgx^tm1And	involves: 129S7/SvEvBrd * C57BL/6J	MGI:3043032
hm2	Drgx^tm1And/Drgx^tm1And	involves: 129S7/SvEvBrd * C57BL/6J * CD-1b	MGI:3043034

Genotype
MGI:3043032

hm1

• Allelic Composition: Drgx^tm1And/Drgx^tm1And
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:70560 )

• 100% of pups are dead by 3 weeks of age

embryo

abnormal embryonic tissue morphology ( J:70560 )

• embryos showed delayed projections of primary sensory afferents in the dorsal horn, selectively affecting cutaneous afferents

• normal differentiation and development of sensory neurons of the dorsal root ganglia

growth/size/body

decreased body weight ( J:70560 )

• weighed less than wild-type or heterozygous littermate controls

nervous system

abnormal sensory neuron innervation pattern ( J:70560 )

• embryos showed delayed projections of primary sensory afferents in the dorsal horn, selectively affecting cutaneous afferents

• normal differentiation and development of sensory neurons of the dorsal root ganglia

Genotype
MGI:3043034

hm2

• Allelic Composition: Drgx^tm1And/Drgx^tm1And
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * CD-1b

mortality/aging

premature death ( J:70560 )

• 50% of pups survive to adulthood

behavior/neurological

behavior/neurological phenotype ( J:70560 )

N • normal locomotor capabilities in rotarod treadmill test

N • normal locomotion

increased grooming behavior ( J:70560 )

• persistent grooming of dorsal hind limb, beginning at 3 to 4 weeks of age

• resulted in fur loss and skin lesions

hyporesponsive to tactile stimuli ( J:70560 )

• using von Frey filaments

increased chemical nociceptive threshold ( J:70560 )

• reduced responses to capsaicin and to formalin

increased thermal nociceptive threshold ( J:70560 )

• higher latency inn tail-flick test

• higher latency in paw withdrawal tests of thermal sensitivity

• prolonged latency in hot plate test

embryo

abnormal embryonic tissue morphology ( J:70560 )

• embryos showed delayed projections of primary sensory afferents in the dorsal horn, selectively affecting cutaneous afferents

• normal differentiation and development of sensory neurons of the dorsal root ganglia

nervous system

abnormal sensory neuron morphology ( J:70560 )

• loss of neurons in the dorsal horn, especially the lateral-most region

• 60% - 70% loss of dorsal horn neurons at the lumbar level

• no such loss in the ventral horn

abnormal sensory neuron innervation pattern ( J:70560 )

• embryos showed delayed projections of primary sensory afferents in the dorsal horn, selectively affecting cutaneous afferents

• normal differentiation and development of sensory neurons of the dorsal root ganglia