Phenotypes associated with this allele

• Allele Symbol: Traf4^tm1Mrio
• Allele Name: targeted mutation 1, Marie-Christine Rio
• Allele ID: MGI:2182705
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Traf4^tm1Mrio/Traf4^tm1Mrio	involves: 129X1/SvJ	MGI:3849064

Genotype
MGI:3849064

hm1

• Allelic Composition: Traf4^tm1Mrio/Traf4^tm1Mrio
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:76067 )

• reduced frequency of homozygotes after E13.5

reproductive system

decreased litter size ( J:76067 )

• adults fertile but produce very small litters

growth/size/body

decreased embryo size ( J:76067 )

• embryos surviving to E14.5 are morphologically normal but reduced in size

spina bifida cystica ( J:76067 )

• spina bifida aperta in some embryos, exposure of dorsal neuroepithelium

abnormal postnatal growth/weight/body size ( J:76067 )

decreased body weight ( J:76067 )

• adults about 20% lower body mass

decreased body length ( J:76067 )

• adults about 20% smaller than controls

respiratory system

abnormal bronchus morphology ( J:76067 )

• extrapulmonary bronchi malformed and smaller than normal

abnormal trachea morphology ( J:76067 )

abnormal tracheal cartilage morphology ( J:76067 )

• malformed

• frontal interruptions

fused tracheal cartilage rings ( J:76067 )

• sometimes

small trachea ( J:76067 )

• reduced diameter of lumen

wheezing ( J:76067 )

• wheezing sound produced during inspiration

skeleton

abnormal tracheal cartilage morphology ( J:76067 )

• malformed

• frontal interruptions

fused tracheal cartilage rings ( J:76067 )

• sometimes

abnormal sternocostal joint morphology ( J:76067 )

• an 8th right side vertebrosternal rib sometimes

• irregular sternocostal junctions on the 2nd or 3rd sternebrae

asymmetric sternocostal joints ( J:76067 )

• asymmetric junctions of vertebrosternal ribs

abnormal rib morphology ( J:76067 )

rib fusion ( J:76067 )

• some rib fusions

• particularly between the 1st and 2nd right ribs

• also between the 4th and 5th right rib

abnormal vertebral column morphology ( J:76067 )

• abnormal vertebrae

spina bifida occulta ( J:76067 )

• failure of vertebral arches to fuse dorsally

• in all 6 lumbar vertebrae and up to 6 thoracic vertebrae

abnormal intervertebral disk morphology ( J:76067 )

• malformations occur

kyphoscoliosis ( J:76067 )

• combined with a curly tail in animals that fail to survive to adulthood

abnormal vertebral body morphology ( J:76067 )

• malformations

nervous system

spina bifida cystica ( J:76067 )

• spina bifida aperta in some embryos, exposure of dorsal neuroepithelium

spina bifida occulta ( J:76067 )

• failure of vertebral arches to fuse dorsally

• in all 6 lumbar vertebrae and up to 6 thoracic vertebrae

abnormal dorsal root ganglion morphology ( J:76067 )

• located more ventrally than normal

limbs/digits/tail

curly tail ( J:76067 )

• sometimes seen in combination with kyphoscoliosis in animals that fail to survive to adulthood

immune system

immune system phenotype ( J:142780 )

N • normal thymus, spleen, and lymph nodes

N • normal cellular composition of thymus, spleen, lymph nodes, and bone marrow

abnormal dendritic cell physiology ( J:142780 )

• reduced numbers of migrating dendritic cells in response to CCL19 or CCL21

cellular

abnormal cell migration ( J:142780 )

• reduced numbers of migrating dendritic cells in response to CCL19 or CCL21

embryo

decreased embryo size ( J:76067 )

• embryos surviving to E14.5 are morphologically normal but reduced in size

spina bifida cystica ( J:76067 )

• spina bifida aperta in some embryos, exposure of dorsal neuroepithelium

spina bifida occulta ( J:76067 )

• failure of vertebral arches to fuse dorsally

• in all 6 lumbar vertebrae and up to 6 thoracic vertebrae