All Phenotypes Cd40lg<tm1Flv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd40lg^tm1Flv/Cd40lg^tm1Flv	involves: 129S2/SvPas * C57BL/6	MGI:2449454
hm2	Cd40lg^tm1Flv/Cd40lg^tm1Flv	NOD.129S2-Cd40lg^tm1Flv	MGI:3640354
cx3	Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr	involves: 129P2/OlaHsd * 129S2/SvPas * MRL	MGI:4947941
cx4	Cd40lg^tm1Flv/Y Fas^lpr/Fas^lpr	involves: 129P2/OlaHsd * 129S2/SvPas * MRL	MGI:4947942
cx5	Cd40lg^tm1Flv/Y Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo	involves: 129P2/OlaHsd * 129S2/SvPas * MRL	MGI:4947943
cx6	Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo	involves: 129P2/OlaHsd * 129S2/SvPas * MRL	MGI:4947944
cx7	Cd40lg^tm1Flv/Cd40lg^tm1Flv Tg(APPSWE)2576Kha/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:2653196
cx8	Cd28^tm1Mak/Cd28^tm1Mak Cd40lg^tm1Flv/Cd40lg^tm1Flv	NOD.Cg-Cd40lg^tm1Flv Cd28^tm1Mak	MGI:3640356

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune system morphology ( J:25010 )

abnormal osteoclast differentiation ( J:120087 )

• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma

• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation

• suppression of signaling via NF-kappaB ligand decreases osteoclast formation

abnormal T cell differentiation ( J:25010 )

decreased double-positive T cell number ( J:25010 )

• slightly decreased number of double positive thymocytes

increased CD4-positive, alpha-beta T cell number ( J:25010 )

• slight increase in the thymus and spleen although the ratio of CD4+ to Cd8+ cells in the spleen is normal

absent spleen germinal center ( J:25010 )

• no germinal center B cells in the spleens of immunized homozygotes but the architecture of the spleen is normal

abnormal immune system physiology ( J:25010 )

abnormal adaptive immunity ( J:25010 )

• primary response to T cell dependent antigens is severely reduced

• secondary response to T cell dependent antigens is lost

• T cell independent antibody responses are unaffected

abnormal class switch recombination ( J:25010 )

decreased immunoglobulin level ( J:25010 )

decreased IgA level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgD level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgE level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgG1 level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgG3 level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

abnormal T-helper 2 physiology ( J:25010 )

• CD4+ T cells unable to drive isotype switching from IgM to IgG1 although IgM levels remain normal

skeleton

abnormal osteoclast differentiation ( J:120087 )

• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma

• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation

• suppression of signaling via NF-kappaB ligand decreases osteoclast formation

hematopoietic system

abnormal osteoclast differentiation ( J:120087 )

• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma

• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation

• suppression of signaling via NF-kappaB ligand decreases osteoclast formation

abnormal class switch recombination ( J:25010 )

abnormal T cell differentiation ( J:25010 )

decreased double-positive T cell number ( J:25010 )

• slightly decreased number of double positive thymocytes

increased CD4-positive, alpha-beta T cell number ( J:25010 )

• slight increase in the thymus and spleen although the ratio of CD4+ to Cd8+ cells in the spleen is normal

absent spleen germinal center ( J:25010 )

• no germinal center B cells in the spleens of immunized homozygotes but the architecture of the spleen is normal

decreased immunoglobulin level ( J:25010 )

decreased IgA level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgD level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgE level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgG1 level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgG3 level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

abnormal T-helper 2 physiology ( J:25010 )

• CD4+ T cells unable to drive isotype switching from IgM to IgG1 although IgM levels remain normal

cellular

abnormal osteoclast differentiation ( J:120087 )

• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma

• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation

• suppression of signaling via NF-kappaB ligand decreases osteoclast formation

Allelic Composition	Cd40lg^tm1Flv/Cd40lg^tm1Flv
Genetic Background	NOD.129S2-Cd40lg^tm1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Flv mutation (1 available); any Cd40lg mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased regulatory T cell number ( J:93421 )

• mice display moderate but significant reduction in numbers of Tregs compared to NOD controls

decreased susceptibility to autoimmune diabetes ( J:93421 )

• mice do not develop diabetes

hematopoietic system

decreased regulatory T cell number ( J:93421 )

• mice display moderate but significant reduction in numbers of Tregs compared to NOD controls

Allelic Composition	Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Flv mutation (1 available); any Cd40lg mutation (16 available)
Fas^lpr mutation (39 available); any Fas mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:38492 )

• relative to mutant mice wild-type for Cd40lg

immune system

decreased immunoglobulin level ( J:38492 )

• lower titers of immunoglobulins compared to mutant mice wild-type for Cd40lg

decreased IgG level ( J:38492 )

• lower titers of IgG1, IgG2a dna IgG2b compared to mice homozygous for Fas^lpr and Cd40lg^tm1Flv

decreased autoantibody level ( J:38492 )

• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg

integument

alopecia ( J:38492 )

• develop severe hair loss by 24 weeks of age

skin lesions ( J:38492 )

• develop scabs and purpuric lesions of the dorsal neck and ears by 24 weeks of age

renal/urinary system

abnormal kidney morphology ( J:38492 )

• substantial reduction in renal disease compared to mutant mice wild-type for Cd40lg

hematopoietic system

decreased immunoglobulin level ( J:38492 )

• lower titers of immunoglobulins compared to mutant mice wild-type for Cd40lg

decreased IgG level ( J:38492 )

• lower titers of IgG1, IgG2a dna IgG2b compared to mice homozygous for Fas^lpr and Cd40lg^tm1Flv

Allelic Composition	Cd40lg^tm1Flv/Y Fas^lpr/Fas^lpr
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:38492 )

• relative to mutant mice wild-type for Cd40lg

immune system

decreased immunoglobulin level ( J:38492 )

• lower titers of immunoglobulins compared to mutant mice wild-type for Cd40lg

decreased IgG level ( J:38492 )

• lower titers of IgG1, IgG2a dna IgG2b compared to mice homozygous for Fas^lpr and Cd40lg^tm1Flv

decreased autoantibody level ( J:38492 )

• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg

integument

alopecia ( J:38492 )

• develop severe hair loss by 24 weeks of age

skin lesions ( J:38492 )

• develop scabs and purpuric lesions of the dorsal neck and ears by 24 weeks of age

renal/urinary system

abnormal kidney morphology ( J:38492 )

• substantial reduction in renal disease compared to mutant mice wild-type for Cd40lg

hematopoietic system

decreased immunoglobulin level ( J:38492 )

• lower titers of immunoglobulins compared to mutant mice wild-type for Cd40lg

decreased IgG level ( J:38492 )

• lower titers of IgG1, IgG2a dna IgG2b compared to mice homozygous for Fas^lpr and Cd40lg^tm1Flv

Allelic Composition	Cd40lg^tm1Flv/Y Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased autoantibody level ( J:38492 )

• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg

• decrease in the anti-snRNP and anti-Ig titers relative to mutant mice compared to mutant mice wild-type for Cd40lg

increased anti-double stranded DNA antibody level ( J:38492 )

• relative to mutant mice wild-type for Tcra

integument

integument phenotype ( J:38492 )

N	• do not develop the skin lesions seen in mutant mice wild-type for Tcra and/or Cd40lg

renal/urinary system

abnormal kidney morphology ( J:38492 )

• renal disease is decreased compared to mutant mice wild-type Cd40lg but more diseased than mutant mice wild-type for Tcra

Allelic Composition	Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased autoantibody level ( J:38492 )

• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg

• decrease in the anti-snRNP and anti-Ig titers relative to mutant mice compared to mutant mice wild-type for Cd40lg

increased anti-double stranded DNA antibody level ( J:38492 )

• relative to mutant mice wild-type for Tcra

integument

integument phenotype ( J:38492 )

N	• do not develop the skin lesions seen in mutant mice wild-type for Tcra and/or Cd40lg

renal/urinary system

abnormal kidney morphology ( J:38492 )

• renal disease is decreased compared to mutant mice wild-type Cd40lg but more diseased than mutant mice wild-type for Tcra

Allelic Composition	Cd40lg^tm1Flv/Cd40lg^tm1Flv Tg(APPSWE)2576Kha/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Flv mutation (1 available); any Cd40lg mutation (16 available)
Tg(APPSWE)2576Kha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:80429 )

• no detectable plaques at 12 months of age compared to minimal levels in mice carrying the transgene alone

• 41-51% reduction in beta-amyloid at 16 months as compared to transgene controls

• reduced numbers of large and medium sized plaques in the neocortex and hippocampus

• beta-CTF is reduced relative to alpha-CTF

gliosis ( J:80429 )

• microgliosis and astrocytosis reduced

homeostasis/metabolism

amyloid beta deposits ( J:80429 )

• no detectable plaques at 12 months of age compared to minimal levels in mice carrying the transgene alone

• 41-51% reduction in beta-amyloid at 16 months as compared to transgene controls

• reduced numbers of large and medium sized plaques in the neocortex and hippocampus

• beta-CTF is reduced relative to alpha-CTF

Allelic Composition	Cd28^tm1Mak/Cd28^tm1Mak Cd40lg^tm1Flv/Cd40lg^tm1Flv
Genetic Background	NOD.Cg-Cd40lg^tm1Flv Cd28^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28^tm1Mak mutation (12 available); any Cd28 mutation (52 available)
Cd40lg^tm1Flv mutation (1 available); any Cd40lg mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

insulitis ( J:93421 )

• severe insulitis is observed compared to Cd40lg^tm1Flv single nulls

decreased regulatory T cell number ( J:93421 )

• mice display a dramatic reduction in numbers of Tregs compared to NOD controls and Cd40lg-deficiet NOD mice

increased susceptibility to autoimmune diabetes ( J:93421 )

• mice show increased incidence of diabetes (blood glucose level >300 mg/dl) compared to Cd40lg-deficient NOD mice

endocrine/exocrine glands

insulitis ( J:93421 )

• severe insulitis is observed compared to Cd40lg^tm1Flv single nulls

hematopoietic system

decreased regulatory T cell number ( J:93421 )

• mice display a dramatic reduction in numbers of Tregs compared to NOD controls and Cd40lg-deficiet NOD mice

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