All Phenotypes Cd40lg<tm1Flv> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd40lg^tm1Flv/Cd40lg^tm1Flv	involves: 129S2/SvPas * C57BL/6	MGI:2449454
hm2	Cd40lg^tm1Flv/Cd40lg^tm1Flv	NOD.129S2-Cd40lg^tm1Flv	MGI:3640354
cx3	Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr	involves: 129P2/OlaHsd * 129S2/SvPas * MRL	MGI:4947941
cx4	Cd40lg^tm1Flv/Y Fas^lpr/Fas^lpr	involves: 129P2/OlaHsd * 129S2/SvPas * MRL	MGI:4947942
cx5	Cd40lg^tm1Flv/Y Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo	involves: 129P2/OlaHsd * 129S2/SvPas * MRL	MGI:4947943
cx6	Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo	involves: 129P2/OlaHsd * 129S2/SvPas * MRL	MGI:4947944
cx7	Cd40lg^tm1Flv/Cd40lg^tm1Flv Tg(APPSWE)2576Kha/0	involves: 129S2/SvPas * C57BL/6 * SJL	MGI:2653196
cx8	Cd28^tm1Mak/Cd28^tm1Mak Cd40lg^tm1Flv/Cd40lg^tm1Flv	NOD.Cg-Cd40lg^tm1Flv Cd28^tm1Mak	MGI:3640356

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal immune system morphology ( J:25010 )

abnormal osteoclast differentiation ( J:120087 )

• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma

• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation

• suppression of signaling via NF-kappaB ligand decreases osteoclast formation

abnormal T cell differentiation ( J:25010 )

decreased double-positive T cell number ( J:25010 )

• slightly decreased number of double positive thymocytes

increased CD4-positive, alpha-beta T cell number ( J:25010 )

• slight increase in the thymus and spleen although the ratio of CD4+ to Cd8+ cells in the spleen is normal

absent spleen germinal center ( J:25010 )

• no germinal center B cells in the spleens of immunized homozygotes but the architecture of the spleen is normal

abnormal immune system physiology ( J:25010 )

abnormal adaptive immunity ( J:25010 )

• primary response to T cell dependent antigens is severely reduced

• secondary response to T cell dependent antigens is lost

• T cell independent antibody responses are unaffected

abnormal class switch recombination ( J:25010 )

decreased immunoglobulin level ( J:25010 )

decreased IgA level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgD level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgE level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgG1 level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgG3 level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

abnormal T-helper 2 physiology ( J:25010 )

• CD4+ T cells unable to drive isotype switching from IgM to IgG1 although IgM levels remain normal

skeleton

abnormal osteoclast differentiation ( J:120087 )

• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma

• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation

• suppression of signaling via NF-kappaB ligand decreases osteoclast formation

hematopoietic system

abnormal osteoclast differentiation ( J:120087 )

• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma

• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation

• suppression of signaling via NF-kappaB ligand decreases osteoclast formation

abnormal class switch recombination ( J:25010 )

abnormal T cell differentiation ( J:25010 )

decreased double-positive T cell number ( J:25010 )

• slightly decreased number of double positive thymocytes

increased CD4-positive, alpha-beta T cell number ( J:25010 )

• slight increase in the thymus and spleen although the ratio of CD4+ to Cd8+ cells in the spleen is normal

absent spleen germinal center ( J:25010 )

• no germinal center B cells in the spleens of immunized homozygotes but the architecture of the spleen is normal

decreased immunoglobulin level ( J:25010 )

decreased IgA level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgD level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgE level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgG1 level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

decreased IgG3 level ( J:25010 )

• level is profoundly reduced in older animals, but is normal at 6 weeks of age

abnormal T-helper 2 physiology ( J:25010 )

• CD4+ T cells unable to drive isotype switching from IgM to IgG1 although IgM levels remain normal

cellular

abnormal osteoclast differentiation ( J:120087 )

• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma

• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation

• suppression of signaling via NF-kappaB ligand decreases osteoclast formation

Allelic Composition	Cd40lg^tm1Flv/Cd40lg^tm1Flv
Genetic Background	NOD.129S2-Cd40lg^tm1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Flv mutation (1 available); any Cd40lg mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased regulatory T cell number ( J:93421 )

• mice display moderate but significant reduction in numbers of Tregs compared to NOD controls

decreased susceptibility to autoimmune diabetes ( J:93421 )

• mice do not develop diabetes

hematopoietic system

decreased regulatory T cell number ( J:93421 )

• mice display moderate but significant reduction in numbers of Tregs compared to NOD controls

Allelic Composition	Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Flv mutation (1 available); any Cd40lg mutation (17 available)
Fas^lpr mutation (39 available); any Fas mutation (82 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:38492 )

• relative to mutant mice wild-type for Cd40lg

immune system

decreased immunoglobulin level ( J:38492 )

• lower titers of immunoglobulins compared to mutant mice wild-type for Cd40lg

decreased IgG level ( J:38492 )

• lower titers of IgG1, IgG2a dna IgG2b compared to mice homozygous for Fas^lpr and Cd40lg^tm1Flv

decreased autoantibody level ( J:38492 )

• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg

integument

alopecia ( J:38492 )

• develop severe hair loss by 24 weeks of age

skin lesions ( J:38492 )

• develop scabs and purpuric lesions of the dorsal neck and ears by 24 weeks of age

renal/urinary system

abnormal kidney morphology ( J:38492 )

• substantial reduction in renal disease compared to mutant mice wild-type for Cd40lg

hematopoietic system

decreased immunoglobulin level ( J:38492 )

• lower titers of immunoglobulins compared to mutant mice wild-type for Cd40lg

decreased IgG level ( J:38492 )

• lower titers of IgG1, IgG2a dna IgG2b compared to mice homozygous for Fas^lpr and Cd40lg^tm1Flv

Allelic Composition	Cd40lg^tm1Flv/Y Fas^lpr/Fas^lpr
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

extended life span ( J:38492 )

• relative to mutant mice wild-type for Cd40lg

immune system

decreased immunoglobulin level ( J:38492 )

• lower titers of immunoglobulins compared to mutant mice wild-type for Cd40lg

decreased IgG level ( J:38492 )

• lower titers of IgG1, IgG2a dna IgG2b compared to mice homozygous for Fas^lpr and Cd40lg^tm1Flv

decreased autoantibody level ( J:38492 )

• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg

integument

alopecia ( J:38492 )

• develop severe hair loss by 24 weeks of age

skin lesions ( J:38492 )

• develop scabs and purpuric lesions of the dorsal neck and ears by 24 weeks of age

renal/urinary system

abnormal kidney morphology ( J:38492 )

• substantial reduction in renal disease compared to mutant mice wild-type for Cd40lg

hematopoietic system

decreased immunoglobulin level ( J:38492 )

• lower titers of immunoglobulins compared to mutant mice wild-type for Cd40lg

decreased IgG level ( J:38492 )

• lower titers of IgG1, IgG2a dna IgG2b compared to mice homozygous for Fas^lpr and Cd40lg^tm1Flv

Allelic Composition	Cd40lg^tm1Flv/Y Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased autoantibody level ( J:38492 )

• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg

• decrease in the anti-snRNP and anti-Ig titers relative to mutant mice compared to mutant mice wild-type for Cd40lg

increased anti-double stranded DNA antibody level ( J:38492 )

• relative to mutant mice wild-type for Tcra

integument

integument phenotype ( J:38492 )

N	• do not develop the skin lesions seen in mutant mice wild-type for Tcra and/or Cd40lg

renal/urinary system

abnormal kidney morphology ( J:38492 )

• renal disease is decreased compared to mutant mice wild-type Cd40lg but more diseased than mutant mice wild-type for Tcra

Allelic Composition	Cd40lg^tm1Flv/Cd40lg^tm1Flv Fas^lpr/Fas^lpr Tcra^tm1Mjo/Tcra^tm1Mjo
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * MRL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased autoantibody level ( J:38492 )

• lower titers autoantibodies compared to mutant mice wild-type for Cd40lg

• decrease in the anti-snRNP and anti-Ig titers relative to mutant mice compared to mutant mice wild-type for Cd40lg

increased anti-double stranded DNA antibody level ( J:38492 )

• relative to mutant mice wild-type for Tcra

integument

integument phenotype ( J:38492 )

N	• do not develop the skin lesions seen in mutant mice wild-type for Tcra and/or Cd40lg

renal/urinary system

abnormal kidney morphology ( J:38492 )

• renal disease is decreased compared to mutant mice wild-type Cd40lg but more diseased than mutant mice wild-type for Tcra

Allelic Composition	Cd40lg^tm1Flv/Cd40lg^tm1Flv Tg(APPSWE)2576Kha/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Flv mutation (1 available); any Cd40lg mutation (17 available)
Tg(APPSWE)2576Kha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

amyloid beta deposits ( J:80429 )

• no detectable plaques at 12 months of age compared to minimal levels in mice carrying the transgene alone

• 41-51% reduction in beta-amyloid at 16 months as compared to transgene controls

• reduced numbers of large and medium sized plaques in the neocortex and hippocampus

• beta-CTF is reduced relative to alpha-CTF

gliosis ( J:80429 )

• microgliosis and astrocytosis reduced

homeostasis/metabolism

amyloid beta deposits ( J:80429 )

• no detectable plaques at 12 months of age compared to minimal levels in mice carrying the transgene alone

• 41-51% reduction in beta-amyloid at 16 months as compared to transgene controls

• reduced numbers of large and medium sized plaques in the neocortex and hippocampus

• beta-CTF is reduced relative to alpha-CTF

Allelic Composition	Cd28^tm1Mak/Cd28^tm1Mak Cd40lg^tm1Flv/Cd40lg^tm1Flv
Genetic Background	NOD.Cg-Cd40lg^tm1Flv Cd28^tm1Mak

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd28^tm1Mak mutation (12 available); any Cd28 mutation (52 available)
Cd40lg^tm1Flv mutation (1 available); any Cd40lg mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

insulitis ( J:93421 )

• severe insulitis is observed compared to Cd40lg^tm1Flv single nulls

decreased regulatory T cell number ( J:93421 )

• mice display a dramatic reduction in numbers of Tregs compared to NOD controls and Cd40lg-deficiet NOD mice

increased susceptibility to autoimmune diabetes ( J:93421 )

• mice show increased incidence of diabetes (blood glucose level >300 mg/dl) compared to Cd40lg-deficient NOD mice

endocrine/exocrine glands

insulitis ( J:93421 )

• severe insulitis is observed compared to Cd40lg^tm1Flv single nulls

hematopoietic system

decreased regulatory T cell number ( J:93421 )

• mice display a dramatic reduction in numbers of Tregs compared to NOD controls and Cd40lg-deficiet NOD mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24