Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gadd45gtm1Jni targeted mutation 1, James N Ihle MGI:2182734 |
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| Summary |
5 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• hematopoiesis in homozygous mice is not impaired
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| N |
• T cells from homozygous mice exhibit normal proliferative responses to IL-2
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• histologically some XY ovaries appear similar to XX ovaries while others are hypoplastic with very few or no follicles
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• some XY ovaries are hypoplastic with very few or no follicles
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• ovaries in XY females appear smaller than in XX wild-type females when examined microscopically
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• commonly detected in XY ovaries
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• expression analysis indicates disruption of expression of testis determining genes
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• reproductive tracts of XY mice have a predominantly female phenotype with identifiable ovaries and oviduct and uterine structures
• histologically some XY ovaries appear similar to XX ovaries while others are hypoplastic with very few or no follicles
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• reproductive tracts of XY mice have a predominantly female phenotype with identifiable ovaries and oviduct and uterine structures
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• sex reversed XY females are infertile; but exhibit normal mating behavior
• XX female mice are fertile
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• histologically some XY ovaries appear similar to XX ovaries while others are hypoplastic with very few or no follicles
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• some XY ovaries are hypoplastic with very few or no follicles
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• ovaries in XY females appear smaller than in XX wild-type females when examined microscopically
|
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• commonly detected in XY ovaries
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• expression analysis indicates disruption of expression of testis determining genes
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• commonly detected in XY ovaries
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• significant numbers of Stra8-positive meiotic germ cells are detectable at the poles of XY gonads at E14.5 indicating a activation of ovarian pathways
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• significant numbers of Stra8-positive meiotic germ cells are detectable at the poles of XY gonads at E14.5 indicating a activation of ovarian pathways
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• severe disruption of testis determination
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• about 50% of XY mice develop ovotestes with varying degrees of testicular tissue at E14.5
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• about 50% of XY mice develop gonads with ovarian morphology at E14.5
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• severe disruption of testis determination
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 N |
• testis determination and development in XY mice are similar to wild-type XY controls, unlike in mice not carrying the transgene
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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