Phenotypes associated with this allele

• Allele Symbol: Ets1^tm1Fwa
• Allele Name: targeted mutation 1, Frederick W Alt
• Allele ID: MGI:2182735
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ets1^tm1Fwa/Ets1^tm1Fwa	B6.129S4-Ets1^tm1Fwa	MGI:3833430

Genotype
MGI:3833430

hm1

• Allelic Composition: Ets1^tm1Fwa/Ets1^tm1Fwa
• Genetic Background: B6.129S4-Ets1^tm1Fwa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:93454 , J:93845 )

• although found in normal Mendelian ratios at E18.5, only 2% of mice are present at weaning compared to the expected 25% (J:93454)

immune system

immune system phenotype ( J:93845 )

N • despite impaired B cell development and activation, recombination of the heavy chain locus and BCR complex function are normal

increased B cell apoptosis ( J:93845 )

• following activation with anti-IgM

decreased B cell proliferation ( J:93845 )

• B cells fail to proliferate in response to anti-IgM unlike wild-type cells

• B cell proliferation in response to LPS is decreased compared to wild-type cells

abnormal B cell differentiation ( J:93845 )

• early B cell development is impaired at both the IgM+ and IgM- stages

• splenic B cell development in Rag2 null chimeras is impaired

decreased pro-B cell number ( J:93845 )

• the percentage of B220+IgM- pro-B cells in bone marrow is reduced to 31% compared to 37% in wild-type mice

increased pro-B cell number ( J:93845 )

• the percentage of B220+CD43+ pro-B cells in bone marrow is increased compared to in wild-type mice

• the percentage of CD43+ pro-B cells in bone marrow is increased compared to in wild-type mice

decreased B cell number ( J:93845 )

• bone marrow and fetal livers contain fewer B220+ B cells than in wild-type mice

• the number of B220+CD43- B cells in the femur is decreased 6-fold compared to in wild-type mice

• the number of B220+CD43+ B cells in the femur is decreased 2-fold compared to in wild-type mice

• the number of B220+CD43+ B cells in the fetal liver is decreased compared to in wild-type mice

decreased mature B cell number ( J:93845 )

• the percentage of B220+CD43-IgM+ B cells in bone marrow is reduced to 15% compared to 36% in wild-type mice

absent B-1a cells ( J:93845 )

growth/size/body

decreased body weight ( J:93454 , J:93845 )

• at 4 weeks, mice weigh less than 50% of wild-type (J:93454)

• at 4 weeks, mice weigh less than 50% of wild-type (J:93845)

postnatal growth retardation ( J:93454 , J:93845 )

hematopoietic system

increased B cell apoptosis ( J:93845 )

• following activation with anti-IgM

decreased B cell proliferation ( J:93845 )

• B cells fail to proliferate in response to anti-IgM unlike wild-type cells

• B cell proliferation in response to LPS is decreased compared to wild-type cells

abnormal B cell differentiation ( J:93845 )

• early B cell development is impaired at both the IgM+ and IgM- stages

• splenic B cell development in Rag2 null chimeras is impaired

decreased pro-B cell number ( J:93845 )

• the percentage of B220+IgM- pro-B cells in bone marrow is reduced to 31% compared to 37% in wild-type mice

increased pro-B cell number ( J:93845 )

• the percentage of B220+CD43+ pro-B cells in bone marrow is increased compared to in wild-type mice

• the percentage of CD43+ pro-B cells in bone marrow is increased compared to in wild-type mice

decreased B cell number ( J:93845 )

• bone marrow and fetal livers contain fewer B220+ B cells than in wild-type mice

• the number of B220+CD43- B cells in the femur is decreased 6-fold compared to in wild-type mice

• the number of B220+CD43+ B cells in the femur is decreased 2-fold compared to in wild-type mice

• the number of B220+CD43+ B cells in the fetal liver is decreased compared to in wild-type mice

decreased mature B cell number ( J:93845 )

• the percentage of B220+CD43-IgM+ B cells in bone marrow is reduced to 15% compared to 36% in wild-type mice

absent B-1a cells ( J:93845 )

cellular

increased B cell apoptosis ( J:93845 )

• following activation with anti-IgM

decreased B cell proliferation ( J:93845 )

• B cells fail to proliferate in response to anti-IgM unlike wild-type cells

• B cell proliferation in response to LPS is decreased compared to wild-type cells