Phenotypes associated with this allele

• Allele Symbol: Gadd45g^tm1Flv
• Allele Name: targeted mutation 1, Richard A Flavell
• Allele ID: MGI:2182738
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gadd45g^tm1Flv/Gadd45g^tm1Flv	involves: 129S1/Sv	MGI:3839894
cx2	Gadd45b^tm1Flv/Gadd45b^tm1Flv Gadd45g^tm1Flv/Gadd45g^tm1Flv	involves: 129S1/Sv * 129S6/SvEvTac	MGI:3839902
cx3	Gadd45b^tm1Flv/Gadd45b^tm1Flv Gadd45g^tm1Flv/Gadd45g^tm1Flv	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:3839942

Genotype
MGI:3839894

hm1

• Allelic Composition: Gadd45g^tm1Flv/Gadd45g^tm1Flv
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown adipose tissue physiology ( J:213702 )

• norepinephrine-treated cultured brown adipocytes fail to exhibit an increase in basal oxygen consumption unlike wild-type cells

immune system

abnormal T-helper 1 cell differentiation ( J:87396 )

• there is a slight reduction in Th1 T cell production after infection with Listera monocytogenes

abnormal NK cell physiology ( J:87396 )

• NK cells produce less IFN-gamma after stimulation with IL-12 and IL-18

abnormal T-helper 1 physiology ( J:69475 )

• T cells cultured under Th1 polarizing conditions produce half to two-thirds less IFN-gamma when activated

• reactivated Th1 T cells are resistant to activation-induced cell death when cultured with low doses of anti-CD3 antibodies

abnormal type IV hypersensitivity reaction ( J:69475 )

• ear swelling responses to dinitrofluorobenzene challenge are half to a two-thirds less than in wild-type controls

decreased interferon-gamma secretion ( J:69475 , J:87396 )

• T cells cultured under Th1 polarizing conditions produce half to two-thirds less IFN-gamma when activated (J:69475)

• NK cells produce less IFN-gamma after stimulation with IL-12 and IL-18 (J:87396)

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:87396 )

• there is a slight reduction in Th1 T cell production after infection with Listera monocytogenes

abnormal NK cell physiology ( J:87396 )

• NK cells produce less IFN-gamma after stimulation with IL-12 and IL-18

abnormal T-helper 1 physiology ( J:69475 )

• T cells cultured under Th1 polarizing conditions produce half to two-thirds less IFN-gamma when activated

• reactivated Th1 T cells are resistant to activation-induced cell death when cultured with low doses of anti-CD3 antibodies

homeostasis/metabolism

impaired adaptive thermogenesis ( J:213702 )

• in cold-exposed mice

decreased core body temperature ( J:213702 )

• in cold-exposed mice

Genotype
MGI:3839902

cx2

• Allelic Composition: Gadd45b^tm1Flv/Gadd45b^tm1Flv; Gadd45g^tm1Flv/Gadd45g^tm1Flv
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac

immune system

abnormal T-helper 1 cell differentiation ( J:87396 )

• Th1 T cell production is severely reduced after infection with Listera monocytogenes compared to controls

hematopoietic system

abnormal T-helper 1 cell differentiation ( J:87396 )

• Th1 T cell production is severely reduced after infection with Listera monocytogenes compared to controls

Genotype
MGI:3839942

cx3

• Allelic Composition: Gadd45b^tm1Flv/Gadd45b^tm1Flv; Gadd45g^tm1Flv/Gadd45g^tm1Flv
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

immune system

spleen hyperplasia ( J:118837 )

• mice have severe splenomegaly by 10 months of age with cellularity at least 3-fold greater than in controls

• increases size is from an increased number of memory CD4⁺ T cells and B cells

increased mature B cell number ( J:118837 )

• increased mature B cell numbers are found in the spleen of 10 month old mice

increased memory T cell number ( J:118837 )

• increased memory/effector (CD4⁺ CD44⁺) T cells are found in the spleen of 10 month old mice

increased IgG1 level ( J:118837 )

• sera levels of IgG1 are 10-fold higher in mice 10 months of age

increased IgM level ( J:118837 )

• sera levels of IgM are 10-fold higher in mice 10 months of age

increased anti-double stranded DNA antibody level ( J:118837 )

• a large amount of anti-dsDNA IgM and IgG1 is found in the sera of 10 month old mice

increased anti-histone antibody level ( J:118837 )

• a large amount of anti-histone IgM and IgG1 is found in the sera of 10 month old mice

glomerulonephritis ( J:118837 )

• immune complex deposits are found in the glomeruli of 10 month old mice

renal/urinary system

glomerulonephritis ( J:118837 )

• immune complex deposits are found in the glomeruli of 10 month old mice

renal glomerular immunoglobulin deposits ( J:118837 )

hematopoietic system

spleen hyperplasia ( J:118837 )

• mice have severe splenomegaly by 10 months of age with cellularity at least 3-fold greater than in controls

• increases size is from an increased number of memory CD4⁺ T cells and B cells

increased mature B cell number ( J:118837 )

• increased mature B cell numbers are found in the spleen of 10 month old mice

increased memory T cell number ( J:118837 )

• increased memory/effector (CD4⁺ CD44⁺) T cells are found in the spleen of 10 month old mice

increased IgG1 level ( J:118837 )

• sera levels of IgG1 are 10-fold higher in mice 10 months of age

increased IgM level ( J:118837 )

• sera levels of IgM are 10-fold higher in mice 10 months of age

growth/size/body

spleen hyperplasia ( J:118837 )

• mice have severe splenomegaly by 10 months of age with cellularity at least 3-fold greater than in controls

• increases size is from an increased number of memory CD4⁺ T cells and B cells