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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfatc2tm1Rao
targeted mutation 1, Anjana Rao
MGI:2182743
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfatc2tm1Rao/Nfatc2tm1Rao B6.Cg-Nfatc2tm1Rao MGI:3845200
cn2
 		Nfatc1tm1Rao/Nfatc1tm1Rao
Nfatc2tm1Rao/Nfatc2tm1Rao
Cd79atm1(cre)Reth/Cd79a+ 		involves: BALB/c MGI:5295256
cn3
 		Nfatc2tm1Rao/Nfatc2tm1Rao
Nfatc3tm1Grc/Nfatc3tm1Grc
Tg(Lck-cre)I57Jxm/0 		involves: ICR MGI:3820653


Genotype
MGI:3845200
hm1
Allelic
Composition		 Nfatc2tm1Rao/Nfatc2tm1Rao
Genetic
Background		 B6.Cg-Nfatc2tm1Rao
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2tm1Rao mutation (3 available); any Nfatc2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:78089 )
• activated mast cells fail to produce IL-4 after stimulation
• IL-13 and TNF production is also reduced
decreased interleukin-13 secretion ( J:78089 )
• IL-13 production by activated mast cells is reduced
decreased interleukin-4 secretion ( J:78089 )
• mast cells fail to produce IL-4 after stimulation
decreased tumor necrosis factor secretion ( J:78089 )
• TNF production by activated mast cells is reduced

hematopoietic system
abnormal mast cell physiology ( J:78089 )
• activated mast cells fail to produce IL-4 after stimulation
• IL-13 and TNF production is also reduced




Genotype
MGI:5295256
cn2
Allelic
Composition		 Nfatc1tm1Rao/Nfatc1tm1Rao
Nfatc2tm1Rao/Nfatc2tm1Rao
Cd79atm1(cre)Reth/Cd79a+
Genetic
Background		 involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation (3 available); any Cd79a mutation (24 available)
Nfatc1tm1Rao mutation (0 available); any Nfatc1 mutation (49 available)
Nfatc2tm1Rao mutation (3 available); any Nfatc2 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell physiology ( J:177319 )
• stimulated B cells exhibit reduced ability to induced T cell proliferation
decreased interleukin-2 secretion ( J:177319 )
• from stimulated B cells

hematopoietic system
abnormal B cell physiology ( J:177319 )
• stimulated B cells exhibit reduced ability to induced T cell proliferation




Genotype
MGI:3820653
cn3
Allelic
Composition		 Nfatc2tm1Rao/Nfatc2tm1Rao
Nfatc3tm1Grc/Nfatc3tm1Grc
Tg(Lck-cre)I57Jxm/0
Genetic
Background		 involves: ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2tm1Rao mutation (3 available); any Nfatc2 mutation (53 available)
Nfatc3tm1Grc mutation (0 available); any Nfatc3 mutation (71 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased T cell apoptosis ( J:141917 )
• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
• however, the number of T cells initially undergoing apoptosis is normal
abnormal T cell differentiation ( J:141917 )
• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice but is not more severe than in Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
abnormal double-negative T cell morphology ( J:141917 )
• mice exhibit an increase in DN1 and subsequently a more severe decrease in the number of DN4 T cells compared to in wild-type, Nfactc3 null or Nfact2 null mice

hematopoietic system
increased T cell apoptosis ( J:141917 )
• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
• however, the number of T cells initially undergoing apoptosis is normal
abnormal T cell differentiation ( J:141917 )
• T cell development is partially blocked after pre-TCR signaling and the DN4 population is reduced compared to in wild-type mice but is not more severe than in Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
abnormal double-negative T cell morphology ( J:141917 )
• mice exhibit an increase in DN1 and subsequently a more severe decrease in the number of DN4 T cells compared to in wild-type, Nfactc3 null or Nfact2 null mice

cellular
increased T cell apoptosis ( J:141917 )
• the rate of T cells undergoing apoptosis in culture is slightly greater than in wild-type and Nfatc3tm1Grc/Nfatc3tm1Grc Tg(Lck-cre)I57Jxm mice
• however, the number of T cells initially undergoing apoptosis is normal




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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory