Phenotypes associated with this allele

• Allele Symbol: Epha8^tm1Bbd
• Allele Name: targeted mutation 1, Mariano Barbacid
• Allele ID: MGI:2182746
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Epha8^tm1Bbd/Epha8^tm1Bbd	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3039457

Genotype
MGI:3039457

hm1

• Allelic Composition: Epha8^tm1Bbd/Epha8^tm1Bbd
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:41127 )

N • homozygous mutant mice were behaviorally normal and displayed no major differences in any structure of the brain, including the brainstem and cerebellum, relative to wild-type

abnormal axon guidance ( J:41127 )

• retrograde labeling experiments revealed a commissural defect, whereby tectal axons failed to project from the superior colliculus of the midbrain to the contralateral inferior colliculus

abnormal nervous system tract morphology ( J:41127 )

• notably, homozygous mutant mice exhibited an aberrant ipsilateral axonal tract that projected to the ventral region of the cervical spinal cord

• retrograde labeling revealed that these abnormal projections originated from a small subpopulation of superior colliculus neurons

cellular

abnormal axon guidance ( J:41127 )

• retrograde labeling experiments revealed a commissural defect, whereby tectal axons failed to project from the superior colliculus of the midbrain to the contralateral inferior colliculus